{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:14:16Z","timestamp":1761743656855},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1995,11]]},"abstract":"\n Background<\/jats:italic>\n This study was performed to report causes of death or graft loss and to identify possible pretransplant risk factors for death or graft loss in infants after heart transplantation.\n <\/jats:p>\n \n Methods and Results<\/jats:italic>\n Pretransplant risk factors were compared for 153 infants registered for heart transplantation within 90 days of life and transplanted from November 1985 to June 1994. Factors assessed were diagnosis, age at transplantation, race, weight, blood type, sex, donor\/recipient blood type match, sex match, weight ratio, fetal registration, locale of pretransplant waiting period, mechanical ventilation, ischemic time, and the need for atrial septostomy or septectomy pretransplantation. No factor was associated with death or graft loss at 1 month or 1 year. Causes of death or graft loss were determined using clinical course and pathology data when available. Death or grafts lost at 1 month, 1 year, and >1 year were 14, 13, and 15, respectively. Causes of death or graft loss expressed as a percent (at 1 month, 1 year, and >1 year, respectively) were acute rejection (14, 23, 27), chronic rejection and posttransplant coronary disease (0, 8, 47), infectious causes (21, 15, 13), early graft failure (21, 0, 0), technical issues (21, 23, 0), chronic graft dysfunction (0, 15, 0), and miscellaneous (21, 15, 13). The graft loss rate at 1 year was significantly correlated (linear regression,\n r<\/jats:italic>\n 2<\/jats:sup>\n =.66;\n P<\/jats:italic>\n <.05) with the year of transplantation. Actuarial survival in this population was 91% at 1 month, 81% at 1 year, and 73% at 3 years.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n Heart transplantation in the young infant can be performed with acceptable short-term and midterm results. Causes of death or graft loss and survival are similar to adult data. No pretransplant risk factors were identified. The experience level of the transplant team members affects survival. The diagnosis and management of rejection remain a major challenge.\n <\/jats:p>","DOI":"10.1161\/01.cir.92.9.206","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"206-209","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Pretransplant Risk Factors and Causes of Death or Graft Loss After Heart Transplantation During Early Infancy"],"prefix":"10.1161","volume":"92","author":[{"given":"Richard E.","family":"Chinnock","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics (R.E.C., R.L.L., J.R.E.) and Surgery (L.L.B.), Loma Linda University Children\u2019s Hospital and Medical Center and Loma Linda University School of Medicine, Loma Linda, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranae L.","family":"Larsen","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (R.E.C., R.L.L., J.R.E.) and Surgery (L.L.B.), Loma Linda University Children\u2019s Hospital and Medical Center and Loma Linda University School of Medicine, Loma Linda, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet R.","family":"Emery","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (R.E.C., R.L.L., J.R.E.) and Surgery (L.L.B.), Loma Linda University Children\u2019s Hospital and Medical Center and Loma Linda University School of Medicine, Loma Linda, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (R.E.C., R.L.L., J.R.E.) and Surgery (L.L.B.), Loma Linda University Children\u2019s Hospital and Medical Center and Loma Linda University School of Medicine, Loma Linda, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","unstructured":"Chinnock R Baum M Larsen R Bailey L. Rejection management and long-term surveillance of the pediatric heart transplant recipient: the Loma Linda experience. J Heart Lung Transplant. 1993;12(suppl 2):S255-S264."},{"key":"e_1_3_3_2_2","first-page":"66","volume":"13","year":"1994","unstructured":"Boucek MM, Mathis CM, Boucek RJ, Hodgkin DD, Kanakriyeh MS, McCormack J, Gundry SR, Bailey LL. Prospective evaluation of echocardiography for primary rejection surveillance after infant heart transplantation: comparison with endomyocardial biopsy. J Heart Lung Transplant. 1994;13:66-73.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_3_2","first-page":"13","volume":"3","year":"1988","unstructured":"Johnston JK, Mathis CM. Determination of rejection using non-invasive parameters following cardiac transplantation in very early infancy\u2014the Loma Linda experience. Prog Cardiovasc Nurs. 1988;3:13-18.","journal-title":"Prog Cardiovasc Nurs"},{"key":"e_1_3_3_4_2","unstructured":"Chinnock RE Johnston J Baum M Janner D Robie S Larsen R. Signs and symptoms of graft rejection in the infant heart transplant recipient. Cardiology in the Young. 1993;3(suppl 1):59. Abstract."},{"key":"e_1_3_3_5_2","first-page":"561","volume":"13","year":"1994","unstructured":"Hosenpud JD, Novick RJ, Breen TJ, Daily OP. The registry of the International Society for Heart and Lung Transplantation: eleventh official report\u20141994. J Heart Lung Transplant. 1994;13:561-570.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_6_2","first-page":"549","volume":"12","year":"1993","unstructured":"Bourge RC, Naftel DC, Costanzo-Nordin MR, Kirklin JK, Young JB, Kubo SH, Olivari MT, Kasper EK. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1993;12:549-562.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70372-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510470048033"},{"key":"e_1_3_3_9_2","first-page":"161A","volume":"9","year":"1991","unstructured":"Boucek MM, Mathis CM, Chinnock RE, Kanakriyeh MS, Nehlsen-Cannarella S, Gundry SR, Bailey LL, Boucek RJ. Polyclonal versus monoclonal anti-T cell antibody therapy in infant heart transplantation. J Heart Lung Transplant. 1991;9:161A. Abstract.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90808-E"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.92.9.206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:57:55Z","timestamp":1715529475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.92.9.206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1161\/01.CIR.92.9.206"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.92.9.206","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"1995-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}