{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:49:52Z","timestamp":1788540592214,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            No prospective study of the long-term sequelae of more than 10 years after acute deep vein thrombosis exists so far. Therefore, 58 low-risk patients with DVT were included in a prospective study to evaluate the natural history of postthrombotic syndrome.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Clinical and hemodynamic examinations were performed at the time of admission; after 3, 6, and 12 months; after the 2nd, 3rd, 4th, 5th years; and finally after the 12th year. All patients received heparin initially and oral anticoagulants subsequently. After 12 years, 64% of the patients exhibited normal findings. Mild skin changes were found in 28%, marked trophic changes in 5%, and only one venous ulcer occurred. Regular use of compression stockings was reported by 54% of the patients with multilevel thrombosis. Although mean maximum venous outflow was significantly reduced from the acute event to 12 years later (\n            <jats:italic>P<\/jats:italic>\n            &lt;.003) compared with the contralateral leg, a significant (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) improvement was observed 6 months later. Recanalization of calf vein thrombosis was detected by Doppler sonography after 3 months. Sixty-four percent of the multilevel thromboses were recanalized completely or in part after 1 year; in 69%, valvular incompetence was found.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In contrast to earlier reports, this prospective study up to 12 years after deep vein thrombosis demonstrates a low incidence of postthrombotic syndrome by administration of oral anticoagulants and regular compression therapy. However, the adverse clinical event rate (mortality 14%) and a recurrence rate of 24% show that the prognosis after deep vein thrombosis does not appear favorable even in low-risk patients.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.1.74","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":122,"title":["Prospective 12-Year Follow-up Study of Clinical and Hemodynamic Sequelae After Deep Vein Thrombosis in Low-Risk Patients (Zu\u0308rich Study)"],"prefix":"10.1161","volume":"93","author":[{"given":"Ulrich K.","family":"Franzeck","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Schalch","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt A.","family":"Ja\u0308ger","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Schneider","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rg","family":"Grimm","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Bollinger","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Angiology Division, University Hospital, Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb19629.x"},{"key":"e_1_3_2_2_2","first-page":"54","volume":"150","year":"1985","unstructured":"Kakkar VV, Lawrence MS. 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