{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:38:50Z","timestamp":1780328330646,"version":"3.54.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,6,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Insulin-like growth factor-1 (IGF-1) appears to have favorable cardiac effects associated with left ventricular remodeling early after myocardial infarction in the rat. The present study was designed to determine whether IGF-1 combined with growth hormone would be beneficial later as well, when infarct healing and cardiac remodeling have occurred.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Four weeks after coronary occlusion, 36 rats were randomized to IGF-1 (3 mg\u00b7kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7d\n            <jats:sup>\u22121<\/jats:sup>\n            ) plus growth hormone (0.1 mg BID) or to placebo for 4 weeks. Treated rats had significant increases in body weight (22%), while the ratio of heart weight to body weight was unchanged. Under anesthesia, cardiac output (fluorescent microspheres) increased 46%, and systemic vascular resistance decreased by 21% (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) in the treated group; a significant (22%) increase of the cardiac index was limited to treated rats with large myocardial infarctions. Small increases in the reduced left ventricular ejection fractions and left ventricular dP\/dt\n            <jats:sub>max<\/jats:sub>\n            values with treatment were not significant. Treated rats showed a borderline (16%) increase in left ventricular end-diastolic volume (angiography), whereas the ratio of left ventricular end-diastolic volume to body weight was reduced in the treated group.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            IGF-1 plus growth hormone administered to rats with left ventricular failure starting 1 month after MI was associated with substantial body growth, decreased systemic vascular resistance, and increased cardiac output. The failing heart also underwent treatment-induced increases in left and right ventricular weights in proportion to body growth, but left ventricular remodeling was minor, and a decrease in the ratio of left ventricular end-diastolic volume to body weight reflected relatively less chamber dilation compared with controls. A significant interaction between size of the myocardial infarction and treatment was observed for several variables, and IGF-1 and growth hormone increased the cardiac index (\n            <jats:italic>P<\/jats:italic>\n            &lt;.035) in rats with a large myocardial infarction.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.12.2188","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"2188-2196","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Cardiovascular Effects of Insulin-Like Growth Factor-1 and Growth Hormone in Chronic Left Ventricular Failure in the Rat"],"prefix":"10.1161","volume":"93","author":[{"given":"Robert L.","family":"Duerr","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dan","family":"McKirnan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Gim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross G.","family":"Clark","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Chien","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John","family":"Ross","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine (R.L.D., R.D.G., K.R.C., J.R.) and Department of Pathology (M.D.M.), University of California at San Diego; and Genentech, Inc (R.G.C.), South San Francisco, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"H876","volume":"248","year":"1985","unstructured":"Anversa P, Loud AV, Levicky V, Guideri G. 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