{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:42:14Z","timestamp":1792712534721,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The use of stents improves the result after balloon coronary angioplasty. Thrombogenicity of stents is, however, a concern. In the present study, we compared stents with an antithrombotic coating with regular stents.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Regular stents were placed in coronary arteries of pigs receiving no aspirin (group 1; n=8) or aspirin over 4 weeks (group 2, n=10) or 12 weeks (group 3, n=9). Stents coated with heparin (antithrombin III uptake, 5 pmol\/stent) were placed in 7 pigs that did not receive aspirin (group 4). The other animals received aspirin and coated stents with a heparin activity of 12 pmol antithrombin III\/stent (group 5, n=10) or 20 pmol\/stent (group 6, n=10; group 7, n=10). Quantitative arteriography was performed at implantation and after 4 (groups 1, 2, and 4 through 6) or 12 weeks (groups 3 and 7). In an additional 5 animals, five regular and five coated stents (20 pmol\/stent) were placed and explanted after 5 days for examination of the early responses to the implants. Thrombotic occlusion of the regular stent occurred in 9 of 27 in groups 1 through 3. However, in 0 of 30 of the animals receiving high-activity heparin-coated stents (groups 5 through 7), thrombotic stent occlusion was observed (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). Histological analysis at 4 weeks showed that the neointima in group 6 was thicker compared with its control group 2 (259\u00b1104 and 117\u00b136 \u03bcm,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01), but at 12 weeks the thickness was similar (152\u00b161 and 198\u00b149 \u03bcm, respectively). Comparison at 5 days suggested delayed endothelialization of the coating.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            High-activity heparin coating of stents eliminates subacute thrombosis in porcine coronary arteries.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.3.423","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":141,"title":["Reduction in Thrombotic Events With Heparin-Coated Palmaz-Schatz Stents in Normal Porcine Coronary Arteries"],"prefix":"10.1161","volume":"93","author":[{"given":"Peter A.","family":"Ha\u030ardhammar","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen M.M.","family":"van Beusekom","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u030akan U.","family":"Emanuelsson","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd H.","family":"Hofma","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per A.","family":"Albertsson","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter D.","family":"Verdouw","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J.","family":"van der Giessen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam (The Netherlands), and Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.3.1999041"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.2.2962786"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(88)80046-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80240-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884465"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90775-D"},{"key":"e_1_3_2_7_2","unstructured":"Chesebro JH Webster MWI Reeder GS Mock MB Grill DE Bailey KR Steichen S Fuster V. 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