{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:38:19Z","timestamp":1772033899883,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The short-term vasodilator response to prostacyclin (PGI\n            <jats:sub>2<\/jats:sub>\n            ) in patients with primary pulmonary hypertension (PPH) is not only unpredictable but also extremely variable in magnitude. In this retrospective study, we attempted to evaluate in a nonselected population of patients with PPH the degree of vasodilatation achieved during short-term infusion of PGI\n            <jats:sub>2<\/jats:sub>\n            and to investigate whether patients with PPH differed in terms of baseline characteristics and prognoses, according to the level of vasodilatation achieved during initial testing with PGI\n            <jats:sub>2<\/jats:sub>\n            .\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Between 1984 and 1992, 91 consecutive patients with PPH underwent catheterization of the right side of the heart with a short-term vasodilator trial with PGI\n            <jats:sub>2<\/jats:sub>\n            (5 to 10 ng\u00b7kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7min\n            <jats:sup>\u22121<\/jats:sup>\n            ). According to the level of vasodilatation achieved during PGI\n            <jats:sub>2<\/jats:sub>\n            infusion, patients were divided into three groups: nonresponding (NR, n=40), moderately responding (MR, n=42), and highly responding (HR, n=9) patients. All three groups were defined by a decrease in total pulmonary resistance index (TPRi) of &lt;20%, between 20% and 50%, and &gt;50%, respectively, relative to control values. Prolonged oral vasodilator therapy was subsequently started only in MR and HR patients. All patients had long-term oral anticoagulant therapy. The survival rate at 2 years (transplant recipients excluded) was significantly higher in HR patients compared with NR and MR patients (62% versus 38% and 47% survivors, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). Comparisons between groups showed no significant differences in baseline hemodynamics or clinical characteristics except for a longer time between onset of symptoms and diagnosis (ie, first catheterization) of PPH in HR patients than in NR and MR patients (71\u00b161 versus 35\u00b134 and 21\u00b121 months, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;.05).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In this study, patients with PPH exhibiting a decrease in TPRi &gt;50% during short-term PGI\n            <jats:sub>2<\/jats:sub>\n            challenge at the time of diagnosis had longer disease evolutions and better prognoses than patients with a lower vasodilator response.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.3.484","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"484-488","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Clinical Significance of the Pulmonary Vasodilator Response During Short-term Infusion of Prostacyclin in Primary Pulmonary Hypertension"],"prefix":"10.1161","volume":"93","author":[{"given":"Olivier","family":"Raffy","sequence":"first","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Re\u0301za","family":"Azarian","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc\u0327ois","family":"Brenot","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Parent","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Sitbon","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Petitpretz","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Herve\u0301","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duroux","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Tuan","family":"Dinh-Xuan","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u0301rald","family":"Simonneau","sequence":"additional","affiliation":[{"name":"From the Service de Pneumologie et Re\u0301animation Respiratoire, Universite\u0301 Paris-Sud, Ho\u0302pital Antoine Be\u0301cle\u0300re, Clamart, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(51)90020-4"},{"key":"e_1_3_2_2_2","first-page":"491","volume":"10","year":"1991","unstructured":"Kriett JM, Kaye MP. The Registry of the International Society for Heart and Lung Transplantation: eighth official report\u20141991. 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