{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:22:44Z","timestamp":1761578564155},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Restenosis after successful percutaneous transluminal coronary angioplasty is the major factor limiting the long-term effectiveness of this procedure. Neointimal proliferation in response to arterial injury is an important contributor to restenosis. The use of radiation for the treatment of malignant and benign proliferative conditions has been well established. External beam irradiation and endovascular irradiation by use of an after-loading technique have been shown to inhibit neointimal proliferation in experimental models of restenosis. The objective of this study was to investigate whether low-dose irradiation from a \u03b2-particle\u2013emitting stent would inhibit neointimal proliferation after placement in porcine iliac arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Fourteen titanium-mesh stents were implanted in the iliac arteries of nine NIH miniature swine. There were seven \u03b2-particle\u2013emitting radioisotope stents (\n            <jats:sup>32<\/jats:sup>\n            P, activity level 0.14 \u03bcCi) and seven control stents (\n            <jats:sup>31<\/jats:sup>\n            P, nonradioactive). Treatment effect was assessed by angiography and histomorphological examination of the stented iliac segments 28 days after implantation. There was a significant reduction in neointimal area (1.76\u00b10.37 mm\n            <jats:sup>2<\/jats:sup>\n            versus 2.81\u00b11.22 mm\n            <jats:sup>2<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            =.05) and percent area stenosis (24.6\u00b12.9% versus 36.0\u00b110.7%,\n            <jats:italic>P<\/jats:italic>\n            =.02) within the \u03b2-particle\u2013emitting stents compared with the control stents. Neointimal thickness, which was assessed at each wire site, was also significantly less within the treatment stents (0.26\u00b10.04 mm versus 0.38\u00b10.10 mm,\n            <jats:italic>P<\/jats:italic>\n            =.012). Scanning electron microscopy was performed on sections from four stents. This demonstrated endothelialization of both the treatment and control stents. There was no excess inflammatory reaction or fibrosis in the media, adventitia, or perivascular space of vessels treated with the \u03b2-particle\u2013emitting stent compared with control vessels. At 28 days, there was no difference in smooth muscle cell proliferation as measured by the proliferating cell nuclear antigen index.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            A local, continuous source of low-dose endovascular irradiation via a \u03b2-particle\u2013emitting stent inhibits neointimal formation in porcine arteries. This low dose of local irradiation did not prevent endothelialization of the stents. This novel technique offers promise for the prevention of restenosis and warrants further investigation.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.3.529","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"529-536","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":127,"title":["Inhibition of Neointimal Proliferation With Low-Dose Irradiation From a \u03b2-Particle\u2013Emitting Stent"],"prefix":"10.1161","volume":"93","author":[{"given":"John R.","family":"Laird","sequence":"first","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Carter","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Kufs","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Hoopes","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Farb","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh H.","family":"Nott","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Fischell","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Fischell","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim A.","family":"Fischell","sequence":"additional","affiliation":[{"name":"From the Cardiology Service, Walter Reed Army Medical Center, Washington, DC; The Armed Forces Institute of Pathology, Washington, DC; Boston Scientific Corporation, Watertown, Mass (S.H.N.); IsoStent Inc, Dayton, Md (R.E.F., D.R.F.); and the Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tenn (T.A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"crossref","unstructured":"Holmes DR Jr Vlietstra RE Smith HC. Restenosis after percutaneous transluminal coronary angioplasty (PTCA): a report from the PTCA registry of the National Heart Lung and Blood Institute. Am J Cardiol. 1984;53(suppl):77C-81C.","DOI":"10.1016\/0002-9149(84)90752-5"},{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"67G","DOI":"10.1016\/S0002-9149(88)80035-3","volume":"61","year":"1988","unstructured":"Kent KM. Restenosis after percutaneous transluminal coronary angioplasty. Am J Cardiol. 1988;61:67G-70G.","journal-title":"Am J Cardiol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.6.1374"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.4.754"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Califf RM Fortin DF Frid DJ Harlan WR Ohman EM Bengtson JR Nelson CL Tcheng JE Mark DB Stack RS. Restenosis after coronary angioplasty: an overview. J Am Coll Cardiol. 1991;17(suppl):2B-13B.","DOI":"10.1016\/0735-1097(91)90933-Z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80174-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80111-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.79.6.2524293"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.1.105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90126-0"},{"key":"e_1_3_2_11_2","first-page":"327","volume":"49","year":"1983","unstructured":"Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury: smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327-333.","journal-title":"Lab Invest"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.69.3.1873869"},{"key":"e_1_3_2_13_2","first-page":"6512","volume":"67","year":"1990","unstructured":"Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch KR. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res. 1990;67:6512-6519.","journal-title":"Circ Res"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90373-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.127.3.509"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249754"},{"key":"e_1_3_2_17_2","first-page":"865","volume":"14","year":"1988","unstructured":"Borok TL, Bray M, Sinclair I. Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys. 1988;14:865-870.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198668090-00016"},{"key":"e_1_3_2_19_2","first-page":"365","volume":"13","year":"1986","unstructured":"Anthony P, Keys H, Evarts CM. Prevention of heterotopic bone formation with early postoperative irradiation in high risk patients undergoing total hip arthroplasty: comparison of 10 Gy vs. 20 Gy schedules. Int J Radiat Oncol Biol Phys. 1986;13:365-369.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90262-3"},{"key":"e_1_3_2_21_2","first-page":"185A","volume":"21","year":"1993","unstructured":"Shefer A, Eigler NL, Whiting JS. Suppression of intimal hyperplasia after balloon angioplasty with local beta irradiation in rabbits. J Am Coll Cardiol. 1993;21:185A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90283-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90397-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1533"},{"key":"e_1_3_2_25_2","unstructured":"Mazur W Ali NM Dabaghi SF Grinstead WC Abukhalil J Paradise P DeFelice CA Schulz D Berner BM Fajardo LF French BA Raizner AE. High dose rate intracoronary radiation suppresses neointimal proliferation in the stented and ballooned model of porcine restenosis. Circulation. 1994;90(suppl I):I-652. Abstract."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"Verin V Popowski Y Urban P Belenger J Redard M Costa M Widmer M Schwager M Kurtz J Rutishauser W. Intraarterial beta irradiation prevents neointimal hyperplasia in a hypercholesterolemic rabbit restenosis model. J Am Coll Cardiol. 1995;2A:407. Abstract.","DOI":"10.1016\/0735-1097(95)91477-F"},{"key":"e_1_3_2_27_2","unstructured":"Hehrlein C Zimmermann M Metz J Fehsenfeld P von Hodenberg E. Radioactive coronary stent implantation inhibits neointimal proliferation in non-atherosclerotic rabbits. Circulation. 1993;88(suppl I):I-651. Abstract."},{"key":"e_1_3_2_28_2","unstructured":"Hehrlein C Riessen R Gollan T Dsnges K Fehsenfeld P von Hodenberg E. Arterial wall cell distribution after implantation of radioactive stents. Circulation. 1994;90(suppl I):I-597. Abstract."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2956"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.597455"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90476-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.10.580"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01102065"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90303-5"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_3_2_37_2","unstructured":"Hall EJ. Cell-survival curves. In: Hall EJ ed. Radiobiology for the Radiologist. 3rd ed. Philadelphia Pa: J.B. Lippincott Co; 1988:18-38."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","unstructured":"Wiederman JG Marboe C Amols H Schwartz A Weinberger J. Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model: six month follow-up. Circulation. 1994;90(suppl I):I-652. Abstract.","DOI":"10.1016\/0735-1097(94)90397-2"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.5.1423971"},{"key":"e_1_3_2_40_2","unstructured":"Lincoff AM Furst JG Lee P. Local delivery of dexamethasone by an eluting stent attenuates the adverse response to biodegradable polymer in the porcine coronary artery. Circulation. 1993;88(suppl I):I-655. Abstract."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.93.3.529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:32:05Z","timestamp":1715527925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.93.3.529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1161\/01.CIR.93.3.529"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.93.3.529","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]},"assertion":[{"value":"1995-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}