{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:40:51Z","timestamp":1761561651188},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,2,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Considerable experimental evidence exists that neointimal hyperplasia after angioplasty is inhibited by \u03b3-irradiation of the treated arteries. A \u03b2-particle radiation is absorbed in tissue within a shorter distance away from the source than \u03b3-radiation and may be more suitable for localized vessel irradiation. This study outlines a method to implant a \u03b2-particle\u2013emitting radioisotope (\n            <jats:sup>32<\/jats:sup>\n            P; half-life, 14.3 days) into metallic stents. The effects of these stents on the inhibition of neointimal hyperplasia was compared with conventional stents in a rabbit model.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            <jats:sup>32<\/jats:sup>\n            P was produced by irradiation of red amorphous phophorus (\n            <jats:sup>31<\/jats:sup>\n            P) with neutrons and was implanted into Palmaz-Schatz stents (7.5 mm in length) after being kept apart from\n            <jats:sup>31<\/jats:sup>\n            P in a mass separator. The radioisotope was tightly fixed to the stents, and the ion implantation process did not alter the surface texture. Stent activity levels of 4 and 13 \u03bcCi were chosen for the study. Four and 12 weeks after placement of conventional stents and\n            <jats:sup>32<\/jats:sup>\n            P-implanted stents in rabbit iliac arteries, vascular injury and neointima formation were studied by histomorphometry. Immunostaining for smooth muscle cell (SMC) \u03b1-actin was performed to determine SMC cellularity in the neointima. SMCs were quantified by computer-assisted counting of \u03b1-actin immunoreactive cells. Endothelialization of the stents was evaluated by immunostaining for endothelial cell von Willebrand factor. No difference in vessel wall injury was found after placement of conventional and\n            <jats:sup>32<\/jats:sup>\n            P-implanted stents. Neointima formation was potently inhibited by\n            <jats:sup>32<\/jats:sup>\n            P-implanted stents only at an activity level of 13 \u03bcCi after 4 and 12 weeks. Neointimal SMC cellularity was reduced in\n            <jats:sup>32<\/jats:sup>\n            P-implanted stents compared with conventional stents. Radioactive stents were endothelialized after 4 weeks, but endothelialization was less dense than in conventional stents.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Neointima formation in rabbits is markedly suppressed by a \u03b2-particle\u2013emitting stent incorporating the radioisotope\n            <jats:sup>32<\/jats:sup>\n            P. In this model, a dose-response relation with this type of radioactive stent was observed, indicating that a threshold radiation dose must be delivered to inhibit neointima formation after stent placement over the long term.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.4.641","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"641-645","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":110,"title":["Pure \u03b2-ParticleEmitting Stents Inhibit Neointima Formation in Rabbits"],"prefix":"10.1161","volume":"93","author":[{"given":"Christoph","family":"Hehrlein","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Stintz","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Kinscherf","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schlo\u0308sser","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehrhard","family":"Huttel","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Friedrich","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fehsenfeld","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Ku\u0308bler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (C.H., M.S., W.K.) and the Department of Anatomy (R.K.), University of Heidelberg (Germany), and the Forschungszentrum Karlsruhe\/Cyclotron Department (K.S., E.H., L.F., P.F.), Karlsruhe, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90397-2"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1533"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00010-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01102065"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2956"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Verin V Popowski Y Urban P Belenger J Redard M Costa M Widmer M-C Schwager M Kurtz J Rutishauser W. Intraarterial beta irradiation prevents neointimal hyperplasia in a hypercholesterolemic rabbit restenosis model. J Am Coll Cardiol. 1995;special issue (February):2A. Abstract.","DOI":"10.1016\/0735-1097(95)91477-F"},{"key":"e_1_3_2_7_2","unstructured":"Popowski Y Verin V Belenger J Redard M Costa M Widmer M-C Nouet P Rouzard M Papirov I Schwager M Rutishauser W Kutzner J. Intra-arterial yttrium-90 brachytherapy for restenosis prevention. In: Bruggmoser G Mould RF eds. Brachytherapy Review. Freiburg Germany: Oncology Series; 1994:163-165."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1570"},{"key":"e_1_3_2_9_2","unstructured":"Dearnaley G Freeman JH Nelson RS Stephen J eds. Ion Implantation. New York NY: Elsevier; 1973."},{"key":"e_1_3_2_10_2","first-page":"64","volume":"38","year":"1963","unstructured":"Fabricius H, Freitag K, G\u00f6ring S. Some measurements about resolution and isotopic contamination of the Karlsruhe electromagnetic isotope separator. Nucl Instr Methods. 1963;38:64-69.","journal-title":"Nucl Instr Methods"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90476-4"},{"key":"e_1_3_2_12_2","first-page":"581","volume":"6","year":"1995","unstructured":"Hehrlein C, Zimmermann M, Metz J, Ensinger W, K\u00fcbler W. Influence of surface texture and charge on the biocompatibility of endovascular stents. Coron Artery Dis. 1995;6:581-586.","journal-title":"Coron Artery Dis"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Laird JR Carter AJ Kufs WM Hoopes TG Farb A Nott S Fischell RE Fischell DR Virmani R Fischell TA. Inhibition of neointimal proliferation with a beta-particle emitting stent. J Am Coll Cardiol. 1995;special issue (February):287A. Abstract.","DOI":"10.1016\/0735-1097(95)92651-K"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90405-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90204-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(90)90047-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.6.2190"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.597455"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.93.4.641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T15:38:12Z","timestamp":1724945892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.93.4.641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2,15]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,2,15]]}},"alternative-id":["10.1161\/01.CIR.93.4.641"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.93.4.641","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"type":"print","value":"0009-7322"},{"type":"electronic","value":"1524-4539"}],"subject":[],"published":{"date-parts":[[1996,2,15]]},"assertion":[{"value":"1995-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-12-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}