{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:12:05Z","timestamp":1787940725977,"version":"build-2784847793"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    Isolated peripheral pulmonary artery stenosis (PPS) in the adult is rare and frequently unsuspected. We review in this article our experience with 12 adult patients with isolated PPS, half of whom had been previously diagnosed with chronic pulmonary thromboembolic disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    The presentation, evolution, and management of 12 adults with isolated PPS, 17 to 51 years of age (mean, 36.2\u00b19.7 years), were evaluated. Presenting symptoms were dyspnea and fatigue. Three patients had New York Heart Association (NYHA) functional class III or greater. Lung perfusion scans revealed multiple segmental abnormalities in flow distribution in all patients. Oxygen desaturation at rest was present in 4 patients. At catheterization, right ventricular (RV) pressure was suprasystemic in 2 patients, systemic in 1, and more than half-systemic in 7. All had multiple bilateral nonuniform stenoses in segmental and subsegmental arteries. Balloon pulmonary angioplasty (BPA) to decrease RV hypertension and improve pulmonary flow distribution was performed in 11 patients. After BPA, vessel diameter increased &gt;50% in 10 patients, distal pulmonary artery pressure increased \u226530% in 6, and RV pressure decreased &gt;30% in 5. One patient died shortly after BPA as a result of pulmonary hemorrhage. Immediate procedural success was achieved in 9 of 11 patients. At a mean follow-up period of 52\u00b132 months, 7 patients had sustained symptomatic improvement (NYHA class I-II).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    We describe a severe syndrome of isolated PPS in the adult that mimics chronic pulmonary thromboembolic disease. Pulmonary hemodynamics and angiography are required for definitive diagnosis. BPA may offer these patients successful short-term reduction in RV hypertension and alleviation of symptomatology.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.93.7.1417","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:34:42Z","timestamp":1339446882000},"page":"1417-1423","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Isolated Peripheral Pulmonary Artery Stenoses in the Adult"],"prefix":"10.1161","volume":"93","author":[{"given":"Jacqueline","family":"Kreutzer","sequence":"first","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Landzberg","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar J.","family":"Preminger","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie S.","family":"Mandell","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ted","family":"Treves","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne M.","family":"Reid","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Lock","sequence":"additional","affiliation":[{"name":"From the Boston (Mass) Adult Congenital Heart Service, Department of Cardiology, Children\u2019s Hospital and Division of Cardiology, Brigham and Women\u2019s Hospital, Departments of Cardiology (J.K., M.J.L., T.J.P., J.E.L.), Radiology (V.S.M., S.T.T.), and Pathology (L.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.18.4.533"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(63)90149-9"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.29.5.680"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80245-1"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.29.4.514"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80231-2"},{"key":"e_1_3_1_7_2","first-page":"61","volume":"5","year":"1973","unstructured":"Rowe RD. Cardiovascular disease in rubella syndrome. Cardiovasc Clin. 1973;5:61-80.","journal-title":"Cardiovasc Clin"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(64)90154-7"},{"key":"e_1_3_1_9_2","first-page":"661","volume":"73","year":"1980","unstructured":"Vernant P, Corone P, Rossignol AM, Bielman C. 120 cases of the Williams and Beuren syndrome. Arch Mal Coeur Vaiss. 1980;73:661-666.","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1968.02100020377005"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80341-5"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.79.1.125"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80706-2"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90250-S"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90394-G"},{"key":"e_1_3_1_16_2","unstructured":"Benotti JR Grossman W. Pulmonary angiography. In: Grossman W Baim D. Cardiac Catheterization Angiography and Intervention. Philadelphia Pa: Lea & Febiger; 1991:229-243."},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.64.5.6456853"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.67.5.6219829"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(84)80146-0"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38659-3"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","unstructured":"Lock JE. Catheter intervention: balloon angioplasty. In: Lock JE ed. Diagnostic and Interventional Catheterization in Congenital Heart Disease. Boston Mass: Martinus-Nijhoff; 1987:91-110.","DOI":"10.1007\/978-1-4613-2333-4_5"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90239-1"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.42.1289"},{"key":"e_1_3_1_24_2","first-page":"527","volume":"101","year":"1980","unstructured":"Meyrick B, Reid L. Ultrastructural findings in lung biopsy material from children with congenital heart defects. Am J Pathol. 1980;101:527-532.","journal-title":"Am J Pathol"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.5.428"},{"key":"e_1_3_1_26_2","unstructured":"Rowe RD. Pulmonary arterial stenosis. In: Rowe RD. Heart Disease in Infancy and Children. New York NY: Macmillan Publishing Co; 1978:789-801."},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30139-5"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.30.6.776"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90159-4"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.79.5.589"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198401000-00016"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36288-9"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.93.4.883"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979004100713"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.67.1.69"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34808-1"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02775011"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.1.232"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.06071067"},{"key":"e_1_3_1_40_2","first-page":"457","volume":"118","year":"1993","unstructured":"Gonon M, Soler M, Bollinger CT, Imhof E, Elsasser S, Dalquen P, Steinbrich W, Gradel E, Perruchoud AP. Schwere H\u00e4moptoe bei pulmonaler Vaskulitis. Dtsch Med Wochenschr. 1993;118:457-462.","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.1.48"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(87)80110-8"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.6.463"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(69)90256-7"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(70)90020-2"},{"key":"e_1_3_1_46_2","first-page":"1331","volume":"19","year":"1978","unstructured":"Li DK, Seltzer SE, McNeil BJ. V\/Q mismatches unassociated with pulmonary artery embolism: case report and review of the literature. J Nucl Med. 1978;19:1331-1333.","journal-title":"J Nucl Med"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.28.2.129"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.71.2.3155497"},{"key":"e_1_3_1_49_2","first-page":"495","volume":"21","year":"1980","unstructured":"Raju BL, Sakowitz M, Goldfarb R, Akbarzadeh H, Funk E, Lubell D. Lung-scan abnormality in pulmonary artery branch stenosis. J Nucl Med. 1980;21:495-496.","journal-title":"J Nucl Med"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.93.7.1417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T11:50:38Z","timestamp":1715514638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.93.7.1417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1161\/01.CIR.93.7.1417"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.93.7.1417","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"1995-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}