{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:24Z","timestamp":1787162844865,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    The Clamshell Septal Occluder has been used to close various congenital heart defects. The purpose of this study was to evaluate the long-term biological response to this device after placement in the canine heart. Previous in vivo studies with device placement were limited to 60 days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    An atrial septal defect was created in dogs by blade septostomy followed by balloon dilation. Both old and new (redesigned) devices were placed. Angiographic follow-up was performed at 1, 3, and 6 months and 1 and 2 years after device placement with groups of dogs euthanitized at the same intervals. Gross and microscopic assessment was done on the explanted devices. The implants were covered at least 50% by neointima at 1 month and covered completely by 3 months. There was no thrombus formation. Areas of focal hemorrhage were evident at 1 month and were not present at 3 months. The fibrous capsule that covered the device became more densely organized and neovascularized by 2 years. A focal foreign body reaction at the device-tissue interface persisted for 2 years. There were no arm fractures with either the old or new devices in these dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    The Bard Clamshell Septal Occluder is well tolerated in the canine heart for at least 2 years and elicits a normal healing process.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.93.7.1459","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:34:42Z","timestamp":1339446882000},"page":"1459-1463","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Biological Response to Bard Clamshell Septal Occluders in the Canine Heart"],"prefix":"10.1161","volume":"93","author":[{"given":"Micheal A.","family":"Kuhn","sequence":"first","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Latson","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Cheatham","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"McManus","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Kilzer","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Furst","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology, Cleveland (Ohio) Clinic Foundation (M.A.K., L.A.L., J.F.); the Section of Pediatric Cardiology, University of Nebraska Medical Center and Children\u2019s Memorial Hospital, Omaha (J.P.C., B.M., K.L.K.); and the Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (J.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.79.5.2713975"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.82.3.2394001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90551-J"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105093241903"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34867-6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02000270"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.93.7.1459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T11:50:20Z","timestamp":1715514620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.93.7.1459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1161\/01.CIR.93.7.1459"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.93.7.1459","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"1995-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}