{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:39:00Z","timestamp":1771461540352,"version":"3.50.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The regulation of glucose uptake in the dysfunctional but viable myocardium has not been studied previously in humans.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Seven patients with an occluded major coronary artery but no previous infarction were studied twice with 2-[\n            <jats:sup>18<\/jats:sup>\n            F]fluoro-2-deoxy-\n            <jats:sc>d<\/jats:sc>\n            -glucose positron emission tomography, once in the fasting state and once during hyperinsulinemic euglycemic clamping. Myocardial blood flow was measured with [\n            <jats:sup>15<\/jats:sup>\n            O]H\n            <jats:sub>2<\/jats:sub>\n            O. The myocardial region beyond an occluded artery that showed stable wall-motion abnormality represented chronically dysfunctional but viable tissue. Six of the patients were later revascularized, and wall-motion recovery was detected in the corresponding regions, which confirmed viability. A slightly reduced myocardial blood flow was detected in the dysfunctional than in the remote myocardial regions (0.81\u00b10.27 versus 1.02\u00b10.23 mL\u00b7g\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7min\n            <jats:sup>\u22121<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            =.036). In the fasting state, glucose uptake was slightly increased in the dysfunctional regions compared with normal myocardium (15\u00b110 versus 11\u00b110 \u03bcmol\/100 g per minute,\n            <jats:italic>P<\/jats:italic>\n            =.038). During insulin clamping, a striking increase in glucose uptake by insulin was obtained in both the dysfunctional and the normal regions (72\u00b122 and 79\u00b121 \u03bcmol\/100 g per minute, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001, fasting versus clamping).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Contrary to previous suggestions, glucose uptake can be increased strikingly by insulin in chronically dysfunctional but viable myocardium. This demonstrates that insulin control over glucose uptake is preserved in the dysfunctional myocardium and provides a rational basis for metabolic intervention.\n          <\/jats:p>","DOI":"10.1161\/01.cir.93.9.1658","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"1658-1666","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["Glucose Uptake in the Chronically Dysfunctional but Viable Myocardium"],"prefix":"10.1161","volume":"93","author":[{"given":"Maija","family":"Ma\u0308ki","sequence":"first","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Luotolahti","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa-Maria","family":"Voipio-Pulkki","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Ruotsalainen","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Haaparanta","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Solin","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Hartiala","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto","family":"Ha\u0308rko\u0308nen","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; the Research Institute for Brain and Blood Vessels-Akita, Japan (H.I.); and the Accelerator Laboratory, A\u030abo Akademi University (O.S.), Turku, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani","family":"Knuuti","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Physiology (M.M., M.L., J.H.), Nuclear Medicine (M.M., M.L., R.H., J.K.), and Medicine (P.N., L.-M.V.-P.), the Medical Cyclotron-PET Center (U.R.), and the Radiopharmaceutical Chemistry Lab (M.H.), University of Turku, Finland; 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