{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:05:44Z","timestamp":1785895544211,"version":"3.56.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,12,15]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Monoclonal anti-rabbit platelet glycoprotein (GP) IIb\/IIIa antibody (AZ1) was adsorbed onto cellulose polymer\u2013coated intracoronary stents to enhance their thromboresistance. We evaluated the antithrombotic efficacy of AZ1 antibody\u2013eluting stents.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Twenty-three polymer-coated stents with AZ1 antibody bound by passive adsorption (AZ1-eluting) were compared with 23 control polymer-coated stents adsorbed with either no antibody (base-polymer, n=12) or isotype-matched irrelevant antibody (anti-CMV\u2013eluting, n=11) by implantation into balloon-damaged, flow-reduced iliac arteries of New Zealand White rabbits. In 13 animals (acute group), flow measurements were made with transit-time flow probes and platelet adhesion was ascertained by use of\n            <jats:sup>111<\/jats:sup>\n            In-labeled autologous platelets. In the other 10 animals (chronic group), stent occlusion was assessed macroscopically after they were killed 28 days after stenting. Arteries with AZ1-eluting stents had significantly less platelet deposition (15.8\u00b14.5\u00d710\n            <jats:sup>7<\/jats:sup>\n            ) than either base-polymer (32.1\u00b14.3\u00d710\n            <jats:sup>7<\/jats:sup>\n            ) or anti-CMV\u2013eluting (35.2\u00b18.8\u00d710\n            <jats:sup>7<\/jats:sup>\n            ) controls (ANOVA,\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001). Compared with base-polymer or anti-CMV\u2013eluting controls, arteries with AZ1-eluting stents showed a marked reduction in cyclic blood flow variation (\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001) and a significantly greater mean blood flow 2 hours after stent deployment (\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001). There was a significant improvement in the patency rate of AZ1-eluting stents compared with controls at both 2 hours (92% versus 46%,\n            <jats:italic>P<\/jats:italic>\n            =.034) and 28 days (100% versus 40%,\n            <jats:italic>P<\/jats:italic>\n            =.015).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Platelet GP IIb\/IIIa antibody eluting from polymer-coated stents reduces platelet deposition, improves blood flow, virtually abolishes cyclic flow variation, and improves patency rates after stent implantation in a rabbit iliac artery model. Its potential for reducing stent-related thrombosis in humans warrants further evaluation.\n          <\/jats:p>","DOI":"10.1161\/01.cir.94.12.3311","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"3311-3317","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Antithrombotic Potential of Polymer-Coated Stents Eluting Platelet Glycoprotein IIb\/IIIa Receptor Antibody"],"prefix":"10.1161","volume":"94","author":[{"given":"Rajesh K.","family":"Aggarwal","sequence":"first","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah C.","family":"Ireland","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Azrin","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Ezekowitz","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"de Bono","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Gershlick","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Faculty of Medicine, University of Leicester, UK (R.K.A., D.C.I., D.P. de B., A.H.G.); the Division of Cardiology, University of Connecticut, Farmington (M.A.A.); and the Section of Cardiovascular Medicine, Yale University, New Haven, Conn (M.D.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90093-G"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90004-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90228-7"},{"key":"e_1_3_2_4_2","unstructured":"Morice MC Amor M Benveniste E Bunouf P Cribier A Labrunie P Masquet C Petiteau PY. 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