{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:24:39Z","timestamp":1792250679695,"version":"4.4.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>Coronary spasm can be induced by acetylcholine, serotonin, ergonovine, or histamine, all of which cause vasodilation when the endothelium is intact by releasing nitric oxide (NO). Coronary spasm is promptly relieved by nitroglycerin, which vasodilates through its conversion to NO. It is thus possible that NO release may be deficient in the spasm arteries in patients with coronary spastic angina (CSA). The aim of this study was to determine whether NO release is deficient in coronary arteries of patients with CSA.<\/jats:p><jats:p><jats:italic>Methods and Results<\/jats:italic><jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>-monomethyl-<jats:sc>l<\/jats:sc>-arginine (L-NMMA), an inhibitor of NO synthase, was infused into coronary arteries in 21 patients with coronary spastic angina (CSA) and in 28 control patients. Coronary spasm was induced by intracoronary injection of acetylcholine and was documented angiographically in all patients with CSA. L-NMMA dose-dependently decreased basal luminal diameter of coronary arteries in control patients, whereas it had no effect on basal diameter of the spasm arteries in patients with CSA. L-NMMA abolished the dilator response to acetylcholine and enhanced the constrictor response to acetylcholine in control arteries, whereas it had no effect on the constrictor response to acetylcholine in spasm arteries. Intracoronary infusion of<jats:sc>l<\/jats:sc>-arginine did not affect the diameter of spasm or control arteries. The dilator response to nitroglycerin was increased markedly in spasm arteries compared with control ar-teries, whereas response to diltiazem did not differ between them.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>There is a deficiency in endothelial NO activity in spasm arteries, which leads to the supersensitivity of the artery to the vasodilator effect of nitroglycerin and to the vasoconstrictor effect of acetylcholine in patients with CSA. This deficient endothelial NO activity plays an important role in the pathogenesis of coronary spasm.<\/jats:p>","DOI":"10.1161\/01.cir.94.3.266","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:34:42Z","timestamp":1339461282000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":312,"title":["Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina"],"prefix":"10.1161","volume":"94","author":[{"given":"Kiyotaka","family":"Kugiyama","sequence":"first","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Yasue","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okumura","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuteru","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakao","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Motoyama","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Inobe","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kawano","sequence":"additional","affiliation":[{"name":"the Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Yasue H Omote S Takizawa A Nagano M. 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