{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:25:38Z","timestamp":1787887538836,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,5,20]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Spontaneous cervical artery dissections are a relatively common cause of ischemic stroke in young adults. Their mechanism is unknown, though it is generally assumed that an underlying minor form of extracellular matrix defect could exist. The present study tested the hypothesis that aortic and cardiac morphological abnormalities usually seen in patients with heritable connective diseases are more frequent in patients with spontaneous cervical artery dissections than in patients without such dissections.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            We performed a case-control study of 28 case patients with spontaneous cervical artery dissection and 84 control subjects with an ischemic stroke not due to cervical artery dissection. Control subjects were matched to case patients for age (\u00b15 years), sex, and year of hospitalization. The aortic root was more frequently enlarged (ie, diameter &gt;34 mm) in case patients (56%) than in control subjects (15%). Mitral valve prolapse, mitral valve dystrophy, and aortic valve dystrophy were more frequent in case patients than in control subjects. In multivariate analyses, aortic diameter &gt;34 mm was the only variable associated with an increased risk of spontaneous cervical artery dissection (odds ratio, 14.2; 95% CI, 3.2 to 63.6;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            These results suggest that aortic root diameter enlargement is associated with an increased risk of spontaneous cervical artery dissection. This finding is consistent with the idea that a generalized defect of the extracellular matrix is present in patients with spontaneous cervical artery dissection.\n          <\/jats:p>","DOI":"10.1161\/01.cir.95.10.2351","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"2351-2353","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Aortic Root Dilatation in Patients With Spontaneous Cervical Artery Dissection"],"prefix":"10.1161","volume":"95","author":[{"given":"Christophe","family":"Tzourio","sequence":"first","affiliation":[{"name":"the Service de Neurologie (C.T., V.B., M.-G.B.) and Service de Cardiologie (A.C., N.L.), Ho\u0302pital Saint-Antoine, and INSERM U360 (C.T.), Ho\u0302pital Pitie\u0301-Salpe\u0302trie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Cohen","sequence":"additional","affiliation":[{"name":"the Service de Neurologie (C.T., V.B., M.-G.B.) and Service de Cardiologie (A.C., N.L.), Ho\u0302pital Saint-Antoine, and INSERM U360 (C.T.), Ho\u0302pital Pitie\u0301-Salpe\u0302trie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lamisse","sequence":"additional","affiliation":[{"name":"the Service de Neurologie (C.T., V.B., M.-G.B.) and Service de Cardiologie (A.C., N.L.), Ho\u0302pital Saint-Antoine, and INSERM U360 (C.T.), Ho\u0302pital Pitie\u0301-Salpe\u0302trie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vale\u0301rie","family":"Biousse","sequence":"additional","affiliation":[{"name":"the Service de Neurologie (C.T., V.B., M.-G.B.) and Service de Cardiologie (A.C., N.L.), Ho\u0302pital Saint-Antoine, and INSERM U360 (C.T.), Ho\u0302pital Pitie\u0301-Salpe\u0302trie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[{"name":"the Service de Neurologie (C.T., V.B., M.-G.B.) and Service de Cardiologie (A.C., N.L.), Ho\u0302pital Saint-Antoine, and INSERM U360 (C.T.), Ho\u0302pital Pitie\u0301-Salpe\u0302trie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520170009012"},{"key":"e_1_3_2_2_2","first-page":"899","volume":"25","year":"1994","unstructured":"Schievink WI, Michels VV, Piepgras DG. Neurovascular manifestations of heritable connective tissue disorders: a review. Stroke. 1994;25:899-903.","journal-title":"Stroke"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31177-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-683"},{"key":"e_1_3_2_5_2","unstructured":"Beighton P. McKusick's Heritable Disorders of Connective Tissue. 5th ed. St Louis Mo: CV Mosby Co; 1993."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90338-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312202"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.4.3829339"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80228-X"},{"key":"e_1_3_2_10_2","first-page":"1164","volume":"25","year":"1980","unstructured":"Morganroth J, Jones RH, Chen CC, Naito M. Two-dimensional echocardiography in mitral, aortic and tricuspid valve prolapse. Am J Cardiol. 1980;25:1164-1177.","journal-title":"Am J Cardiol"},{"key":"e_1_3_2_11_2","first-page":"345","volume":"88","year":"1995","unstructured":"Benhalima B, Cohen A, Chauvel C, Abergel E, Albo C, Elhadad S, Hobeiche M, Khireddine M, Rozensztajn L, Valty J. Etude morphologique par \u00e9chocardiographie transoesophagienne et aspects cliniques de la rupture de cordage mitral chez le sujet \u00e2g\u00e9. Arch Mal Coeur. 1995;88:345-352.","journal-title":"Arch Mal Coeur"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90971-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.1.776440"},{"key":"e_1_3_2_14_2","first-page":"A193","volume":"46","year":"1996","unstructured":"Brandt T, Orberk E, Hausser I, M\u00fcller-K\u00fcppers M, Anton Lamprecht I, Hacke W. Ultrastructural aberrations of connective tissue components in patients with spontaneous cervicocerebral artery dissections. Neurology. 1996;46:A193. Abstract.","journal-title":"Neurology"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.12.2652"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.95.10.2351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:09:18Z","timestamp":1715530158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.95.10.2351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,20]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,5,20]]}},"alternative-id":["10.1161\/01.CIR.95.10.2351"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.95.10.2351","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,20]]},"assertion":[{"value":"1997-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}