{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:57:40Z","timestamp":1790837860059,"version":"4.1.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,6,17]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The pathogenesis of primary pulmonary hypertension (PPH) is unknown, although in some instances families with multiple affected members suggest a genetic etiology.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            We used microsatellite markers and linkage analysis in a large family with PPH to determine the chromosomal location of their disease gene. We tested a second, ethnically distinct, family for cosegregation of disease with markers from the linked region. We mapped the disease locus\n            <jats:italic>PPH1<\/jats:italic>\n            ; GDB\/HUGO designation (GDB:1381541; July 1996), approved when this work was accepted for publication in abstract form (\n            <jats:italic>Circulation<\/jats:italic>\n            . 1996;94[suppl I]:I-49.), in these families to a 27-cM region on chromosome 2q31-q32, with a maximum lod score of 3.87 associated with markers D2S350 and D2S364.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Cosegregation of this region with disease in different ethnic groups suggests that we mapped an important locus in familial PPH. Careful study of additional families and sporadic cases will be required to confirm this localization of PPH1 and characterize its overall role.\n          <\/jats:p>","DOI":"10.1161\/01.cir.95.12.2603","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"2603-2606","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":120,"title":["Mapping of Familial Primary Pulmonary Hypertension Locus\n            <i>(PPH1)<\/i>\n            to Chromosome 2q31-q32"],"prefix":"10.1161","volume":"95","author":[{"given":"Jane H.","family":"Morse","sequence":"first","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn J.","family":"Barst","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hodge","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk C.","family":"Wilhelmsen","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbjoern G.","family":"Nygaard","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine (J.H.M.), Neurology (A.C.J., T.G.N.), Pediatrics (R.J.B.), and Psychiatry (S.E.H.), Columbia University College of Physicians and Surgeons, New York, NY; Columbia University School of Public Health and New York State Psychiatric Institute, New York, NY (S.E.H.); and Department of Neurology, University of California, San Francisco (K.C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.1.236"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.4_Pt_1.787"},{"key":"e_1_3_2_3_2","first-page":"194","volume":"129","year":"1984","unstructured":"Loyd JE, Primm RK, Newman JH. Familial primary pulmonary hypertension: clinical patterns. Am Rev Respir Dis. 1984;129:194-197.","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.1.7599869"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.5.1208"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.3.848"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Wright DK Manos MM. Sample preparation from paraffin-embedded tissues. In: Innis MA Gelfand DH Sninsky JJ White TJ eds. PCR Protocols. 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Adhesion molecules part I. N Engl J Med. 1996;334;1526-1529.","DOI":"10.1056\/NEJM199606063342308"},{"key":"e_1_3_2_19_2","unstructured":"Morse JH Jones A Barst RA DiBenedetto A Hodge S Nygaard TG. Genetic mapping of primary pulmonary hypertension: evidence for linkage to chromosome 2 in a large family. Circulation. 1996;94[suppl I]:I-49."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.95.12.2603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:38:46Z","timestamp":1715531926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.95.12.2603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6,17]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1997,6,17]]}},"alternative-id":["10.1161\/01.CIR.95.12.2603"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.95.12.2603","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6,17]]},"assertion":[{"value":"1996-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}