{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:23:35Z","timestamp":1780637015535,"version":"3.54.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,3,4]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Previous studies have shown that stents can be inserted in coronary arteries of patients who are subsequently treated safely with antiplatelet therapy only (ticlopidine and\/or aspirin) with a low incidence of stent thrombosis, provided that stent expansion is adequate and there are no other flow-limiting lesions present. However, it is unknown whether ticlopidine combined with aspirin is superior to aspirin alone in preventing stent thrombosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            From March 1993 through July 1995, 801 consecutive patients assigned to receive either aspirin therapy alone (ASA, 264 patients, 348 lesions) or a combination of ticlopidine and aspirin (TIC-ASA, 537 patients, 737 lesions) after a successful stent insertion, in most accomplished with intravascular ultrasound guidance, were evaluated retrospectively. At 1 month, there was no difference in the ASA group compared with the TIC-ASA group in the rate of any stent thrombosis (1.9% versus 1.9%;\n            <jats:italic>P<\/jats:italic>\n            =1), subacute stent thrombosis (1.9% versus 1.3%;\n            <jats:italic>P<\/jats:italic>\n            =.5), cumulative major adverse clinical events (1.9% versus 2.0%;\n            <jats:italic>P<\/jats:italic>\n            =1), and peripheral vascular complications (0.5% versus 0.2%;\n            <jats:italic>P<\/jats:italic>\n            =.3). Medication side effects that required termination of antiplatelet therapy occurred only in 1.9% of patients in the TIC-ASA group (\n            <jats:italic>P<\/jats:italic>\n            =.04).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            At 1-month clinical follow-up, stent thrombosis and other adverse clinical outcomes were not significantly different between the ASA and TIC-ASA groups. Medication side effects occurred only in patients treated with ticlopidine. These results provide further evidence of the safety of treatment with antiplatelet therapy only after optimal stent implantation and support the efficacy of aspirin alone in preventing stent thrombosis.\n          <\/jats:p>","DOI":"10.1161\/01.cir.95.5.1145","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1145-1156","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Results of a Consecutive Series of Patients Receiving Only Antiplatelet Therapy After Optimized Stent Implantation"],"prefix":"10.1161","volume":"95","author":[{"given":"Remo","family":"Albiero","sequence":"first","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hall","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Itoh","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Blengino","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martini","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Centro Cuore Columbus, Milan, Italy, and Toho University Ohashi Hospital (S.N.), Third Department of Internal Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.3.1537128"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90827-N"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1676"},{"key":"e_1_3_1_6_2","first-page":"197A","volume":"25","year":"1995","unstructured":"Blengino S, Nakamura S, Hall P, Maiello L, Rocco E, Finci L, Colombo A. A cost analysis of intravascular ultrasound guided coronary stenting without anticoagulation vs the traditional method of stenting with anticoagulation. J Am Coll Cardiol. 1995;25:197A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.2.215"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)90040-3"},{"key":"e_1_3_1_9_2","unstructured":"Morice MC Bourdonnec C Lefevre T Blanchard D Monassier JP Lienhard Y Commeau P Makowski S Labrunie P Cribier A Joly P. Coronary stenting without coumadin: phase III. Circulation. 1994;90(part 2):I-125. Abstract."},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","unstructured":"Hall P Colombo A Nakamura S Maiello L Blengino S Ferraro M Martini G. A prospective study of Gianturco-Roubin coronary stent implantation without subsequent anticoagulation. Circulation. 1994;90(part 2):I-124. Abstract.","DOI":"10.1016\/0735-1097(95)91661-G"},{"key":"e_1_3_1_11_2","unstructured":"Colombo A Nakamura S Hall P Maiello L Blengino S Martini G. A prospective study of Wiktor coronary stent implantation treated only with antiplatelet therapy. Circulation. 1994;90(part 2):I-124. Abstract."},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","unstructured":"Colombo A Maiello L Nakamura S Hall P Blengino S Finci L Martini G. Preliminary experience of coronary stenting with the MicroTM. Circulation. 1994;90(part 2):I-124. Abstract.","DOI":"10.1016\/0735-1097(95)92450-J"},{"key":"e_1_3_1_13_2","first-page":"50A","volume":"25","year":"1995","unstructured":"Russo RJ, Schatz RA, Sklar MA, Johnson AD, Tobis JM, Teirstein PS. Ultrasound guided coronary stent placement without prolonged systemic anticoagulation. J Am Coll Cardiol. 1995;25:50A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_14_2","first-page":"197A","volume":"25","year":"1995","unstructured":"Blasini R, Mudra H, Schulen H, Regar E, Klauss V, Zitzman E, Paloncy R, Neller P, Neumann FJ, Richardt G, Schmitt C, Schomig A. Intravascular ultrasound guided optimized emergency coronary Palmaz-Schatz stent placement without post procedural systemic anticoagulation. J Am Coll Cardiol. 1995;25:197A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_15_2","unstructured":"Elias J Monassier JP Puel J Grollier G Khalife K Hanssen M Labbe T Boulenc JM Laval G. Medtronic Wiktor stent implantation without coumadin: hospital outcome. Circulation. 1994;90(part 2):I-124. Abstract."},{"key":"e_1_3_1_16_2","unstructured":"Aubry P Royer T Spaulding C Lancelin B Faivre R Henry M Livarek B Rioux P Valette B Masquet C Morice MC Zemour G. A lower rate of complications after Gianturco-Roubin coronary stenting using a new antiplatelet and anticoagulant protocol. Circulation. 1994;90(part 2):I-124. Abstract."},{"key":"e_1_3_1_17_2","unstructured":"Carvalho H Fajadet J Jordan C Cassagneau B Robert G Marco J. Reduction of subacute stent thrombosis rate after coronary stenting using a new anticoagulant protocol. Circulation. 1994;90(part 2):I-125. Abstract."},{"key":"e_1_3_1_18_2","unstructured":"Morice MC Breton C Bunouf P Cattan S Eltchaninoff H Henry M Joly P Livarek B Pillere R Rioux P Spaulding C Zemour G. Coronary stenting without anticoagulant without intravascular ultrasound: results of the French registry. Circulation. 1995;92(suppl I):I-796. Abstract."},{"key":"e_1_3_1_19_2","first-page":"182A","volume":"25","year":"1995","unstructured":"Barragan P, Silvestri M, Sainsous J, Simeoni JB, Bayet G, Bouvier JL, Comet B. Prevention of subacute occlusion after coronary stenting with ticlopidine regimen without intravascular ultrasound guided stenting. J Am Coll Cardiol. 1995;25:182A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_20_2","first-page":"137A","volume":"27","year":"1996","unstructured":"Goods CM, Al-Shaibi KF, Negus BH, Liu MW, Yadav SS, Jain SP, Dean LS, Iyer SS, Parks JM, Roubin GS. Is ticlopidine a necessary component of antiplatelet regimens following coronary artery stenting? J Am Coll Cardiol. 1996;27:137A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_21_2","first-page":"137A","volume":"27","year":"1996","unstructured":"de Jaegere P, Mudra H, Almagor Y, Figulla H, Penn I, Doucet S, Bartorelli A, Hamm C, for the Music Study Investigators. In-hospital and 1-month clinical results of an international study testing the concept of IVUS guided optimized stent expansion alleviating the need of systemic anticoagulation. J Am Coll Cardiol. 1996;27:137A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_22_2","unstructured":"Schomig A Schulen H Blasini R Walter H Hadamitzky M Zitzmann E Richardt G Schmitt C Alt E Neumann F-J. Anticoagulation versus antiplatelet therapy after intracoronary Palmaz-Schatz placement: a prospective randomized trial. Circulation. 1995;92(suppl I):I-280. Abstract."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810250410"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.3.1999040"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90472-2"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.5.8181126"},{"key":"e_1_3_1_27_2","first-page":"P1193","volume":"16","year":"1995","unstructured":"Nakamura S, Hall P, Blengino S, Maiello L, Itoh A, Martini G, Finci L, Colombo A. Reproducibility of intravascular ultrasound measurements. Eur Heart J. 1995;16:P1193. Abstract.","journal-title":"Eur Heart J"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90387-4"},{"key":"e_1_3_1_29_2","first-page":"1886","volume":"66","year":"1990","unstructured":"Theron HT, Lambert CR, Pepine CJ. Video densitometry versus digital calipers for quantitative coronary angiography. Am J Cardiol. 1990;66:1886-1890.","journal-title":"Am J Cardiol"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.78.2.2969312"},{"key":"e_1_3_1_31_2","first-page":"125A","volume":"25","year":"1995","unstructured":"Schuhlen H, Blasini R, Mudra H, Klauss V, Kastrati A, Zitzmann E. Stenting for progressive dissection during PTCA: clinical, angiographic and intravascular ultrasound criteria to define a low-risk group not requiring subsequent anticoagulation. J Am Coll Cardiol. 1995;25:125A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_32_2","first-page":"137A","volume":"27","year":"1996","unstructured":"Morice MC, Valeix B, Marco J, Goy JJ, Commeau P, Reifart N, Voudris V, Serra A, Baardman T. Preliminary results of the MUST Trial: major clinical events during the first month. J Am Coll Cardiol. 1996;27:137A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_33_2","first-page":"137A","volume":"27","year":"1996","unstructured":"Lablance J-M, Bonnet J-L, Grollier G, Danchin N, Bedossa M, Leclercq C, Vahanian A, Bertrand ME. Combined antiplatelet therapy without anticoagulation after stent implantation: the Ticlopidine Aspirin Stent Evaluation (TASTE) Study. J Am Coll Cardiol. 1996;27:137A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_34_2","first-page":"393A","volume":"27","year":"1996","unstructured":"Roberts DK, Arthur A, Bellinger RL, Lewis JE, Hass SI, Parise CA. Reduced Anticoagulation Protocol for Stenting (RAPS) in smaller coronary vessels using intravascular ultrasound guidance: 30 day procedural results. J Am Coll Cardiol. 1996;27:393A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_35_2","first-page":"307A","volume":"27","year":"1996","unstructured":"Russo RJ, Teirstein PS, for the AVID Investigators. Angiography versus intravascular ultrasound-directed stent placement. J Am Coll Cardiol. 1996;27:307A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197815020-00003"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201233260406"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908243210804"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002699"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(88)90042-4"},{"key":"e_1_3_1_41_2","first-page":"105","volume":"64","year":"1990","unstructured":"Hardisty RM, Powling MJ, Nokes TJC. The action of ticlopidine on human platelets: studies on aggregation, secretion, calcium mobilization, and membrane glycoproteins. Thromb Haemost. 1990;64:105-155.","journal-title":"Thromb Haemost"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341702"},{"key":"e_1_3_1_43_2","first-page":"181A","volume":"25","year":"1995","unstructured":"Emanuelsson H, Serruys PW, Belandi J, Bonnier H, Colombo A, Fajadet J, Goy JJ, Heyndrickx G, de Jaegere P, Legrand V, Macaya C, Materne P, Rutsch W, Sigwart U, Suryapranata H. Clinical experience with heparin-coated stents: the Benestent II pilot phase 1. J Am Coll Cardiol. 1995;25:181A. Abstract.","journal-title":"J Am Coll Cardiol"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.95.5.1145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:58:56Z","timestamp":1715533136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.95.5.1145"}},"subtitle":["Comparison of Aspirin Alone Versus Combined Ticlopidine and Aspirin Therapy"],"short-title":[],"issued":{"date-parts":[[1997,3,4]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,3,4]]}},"alternative-id":["10.1161\/01.CIR.95.5.1145"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.95.5.1145","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3,4]]},"assertion":[{"value":"1996-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}