{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:23:51Z","timestamp":1773300231196,"version":"3.50.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Long-term oral administration of\n            <jats:sc>l<\/jats:sc>\n            -arginine has been shown to enhance production of nitric oxide (NO) and to reduce lesion formation. The goal of this study was to determine whether local intramural administration of\n            <jats:sc>l<\/jats:sc>\n            -arginine could enhance NO generation and reduce intimal thickening.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            New Zealand White rabbits (n=27) received a 1% cholesterol diet. For the short-term study, after 1 week of diet, both iliac arteries were balloon injured. Four weeks later, vasoreactivity was assessed angiographically during infusion of acetylcholine (Ach) before and after delivery of\n            <jats:sc>l<\/jats:sc>\n            -arginine or saline into the right or left iliac artery (800 mg\/5 mL; 0.2 mL\/min, 15 minutes) by use of a local drug-delivery balloon. Vessels were then harvested for measurements of NO. For the long-term study, after balloon injury, drugs were delivered as above into the iliac arteries. Two and 4 weeks after\n            <jats:sc>l<\/jats:sc>\n            -arginine delivery, vasoreactivity was determined. Subsequently, the iliac arteries were harvested for histomorphometric analysis and measurements of NO. In the short-term study, local delivery of\n            <jats:sc>l<\/jats:sc>\n            -arginine restored endothelium-dependent vasodilatation (Ach 10\n            <jats:sup>\u22125<\/jats:sup>\n            mol\/L;\n            <jats:sc>l<\/jats:sc>\n            -arginine +35\u00b110%; saline \u221214\u00b15%;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) and enhanced local production of nitrogen oxides (\n            <jats:sc>l<\/jats:sc>\n            -arginine 152\u00b128; saline 78\u00b112 nmol\/L per milligram of tissue per hour;\n            <jats:italic>P<\/jats:italic>\n            &lt;.04). In the long-term study, local administration of\n            <jats:sc>l<\/jats:sc>\n            -arginine enhanced vascular NO production as long as 1 week after the injury (\n            <jats:sc>l<\/jats:sc>\n            -arginine 394.4\u00b1141.6; saline 86.3\u00b134.3 nmol\/L per milligram of tissue per hour;\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) and reduced intimal thickening 4 weeks later (intima\/media ratio:\n            <jats:sc>l<\/jats:sc>\n            -arginine 0.56\u00b10.1; saline 1.40\u00b10.2;\n            <jats:italic>P<\/jats:italic>\n            &lt;.001), largely due to suppression of macrophage accumulation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            A single intramural administration of\n            <jats:sc>l<\/jats:sc>\n            -arginine enhances vascular NO generation and inhibits lesion formation. Local augmentation of NO production at the site of balloon angioplasty may be a novel strategy to prevent restenosis.\n          <\/jats:p>","DOI":"10.1161\/01.cir.95.7.1863","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1863-1869","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Local Intramural Delivery of\n            <scp>l<\/scp>\n            -Arginine Enhances Nitric Oxide Generation and Inhibits Lesion Formation After Balloon Angioplasty"],"prefix":"10.1161","volume":"95","author":[{"given":"Severin P.","family":"Schwarzacher","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai T.","family":"Lim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyin","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Kernoff","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Niebauer","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Cooke","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C.","family":"Yeung","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90752-5"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80196-2"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884465"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.6.8205695"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.6.8205696"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.3.412"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/333664a0"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114081"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90112-G"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.65.3.2548765"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.259.5.C738"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.4.552"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114688"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.64.5.2495869"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.81.5.2139594"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.67.6.2245496"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.3.1999009"},{"key":"e_1_3_1_22_2","unstructured":"Creager MA Girerd XJ Gallagher SJ Coleman S Dzau VJ Cooke JP. l-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. Circulation. 1990;82(suppl III):III-346. Abstract."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92372-9"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.1.85"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.4.8149529"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115937"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90433-2"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1622"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.3.8087946"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.5.8181143"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.5.7513551"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.5.8172852"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.12.3513"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.76.6.980"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118074"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.23.14214"},{"key":"e_1_3_1_37_2","unstructured":"Tsao PS Buigrado R Chan JR Cooke JP. Fluid flow inhibits endothelial adhesiveness and transcriptional replication of V-CAM 1. Circulation. In press."},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1137"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/359067a0"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.2.8044966"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5262.689"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8474"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117078"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.10.3773"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810300420"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90118-7"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.4.8149516"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.95.7.1863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:24:40Z","timestamp":1715531080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.95.7.1863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1161\/01.CIR.95.7.1863"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.95.7.1863","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]},"assertion":[{"value":"1996-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}