{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:13:48Z","timestamp":1790892828232,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,11,18]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            The purpose of this study was to test the hypothesis that cholesterol levels in the high normal range are associated with impaired endothelium-dependent vasodilation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            We studied leg blood flow (LBF) responses to graded intrafemoral artery infusions of the endothelium-dependent vasodilator methacholine chloride (MCh) or the endothelium-independent vasodilator sodium nitroprusside (SNP) in normal volunteers exhibiting a wide range of total cholesterol levels within the normal range (&lt;75th percentile). LBF increased in a dose-dependent fashion in response to the femoral artery infusions of MCh and SNP (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). LBF responses to MCh were significantly blunted (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) in subjects with high normal cholesterol (195\u00b16 mg\/dL, n=13) compared with subjects with low normal cholesterol (146\u00b15 mg\/dL, n=20). Maximal endothelium-dependent vasodilation in the high normal group was decreased by nearly 50% compared with the low normal group (146\u00b113% versus 268\u00b134%,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01). There was a negative correlation between total cholesterol levels and maximal endothelium-dependent vasodilation (total cholestero,l\n            <jats:italic>r<\/jats:italic>\n            =\u2212.41,\n            <jats:italic>P<\/jats:italic>\n            &lt;.02; LDL cholesterol,\n            <jats:italic>r<\/jats:italic>\n            =\u2212.42,\n            <jats:italic>P<\/jats:italic>\n            &lt;.02). On the other hand, LBF responses to the endothelium-independent vasodilator SNP did not differ between groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            These data suggest that an inverse and continuous relationship exists between the prevailing cholesterol level and endothelium-dependent vasodilation. Moreover, cholesterol levels even in the normal range may be associated with endothelial dysfunction, thus potentially contributing to the increased risk of macrovascular disease conferred by cholesterol elevations.\n          <\/jats:p>","DOI":"10.1161\/01.cir.96.10.3287","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"3287-3293","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":151,"title":["Endothelial Dysfunction Is Associated With Cholesterol Levels in the High Normal Range in Humans"],"prefix":"10.1161","volume":"96","author":[{"given":"Helmut O.","family":"Steinberg","sequence":"first","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Bayazeed","sequence":"additional","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger","family":"Hook","sequence":"additional","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Cronin","sequence":"additional","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain D.","family":"Baron","sequence":"additional","affiliation":[{"name":"From the Indiana University Medical Center and the Richard L. 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