{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:54:23Z","timestamp":1790420063449,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,8,5]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Ischemic preconditioning (IPC) attenuates acidosis during prolonged ischemia and improves contractile and metabolic parameters during subsequent reperfusion. Glycogen depletion induced by IPC is proposed as a potential mechanism.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            We studied the influence of manipulations of preischemic glycogen levels (Pre-G, \u03bcmol glucose\/g wet wt) on contractile and metabolic (via\n            <jats:sup>31<\/jats:sup>\n            P\u2013nuclear magnetic resonance) parameters during 30 minutes of ischemia and recovery in four groups of isovolumic rat hearts: First, control (Con, n=18, mean Pre-G, 21.5\u00b10.8); second, after two 5-minute IPC periods (IPC, n=12, Pre-G, 11.3\u00b10.7); third, a control group in which Pre-G was depleted by glucose-free, acetate perfusion (Con-LowG, n=9, Pre-G, 7.9\u00b11.2); and fourth, an IPC group in which Pre-G was raised by glucose and lactate perfusion such that Pre-G was similar to Con (IPC-HiG, n=11, Pre-G, 20\u00b11.4). Manipulation of Pre-G significantly altered the pH fall during 30 minutes of ischemia (Con, 5.76\u00b1.03, Con-LowG, 6.26\u00b1.07; IPC-HiG, 5.91\u00b1.02, IPC, 6.05\u00b1.09). IPC-HiG hearts had significantly worse metabolic recovery (PCr, 70\u00b17 versus 91\u00b13% initial; IPC-HiG versus IPC,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) and contractile recovery (end-diastolic pressure, 52\u00b15 versus 29\u00b15 mm Hg,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) than IPC hearts but better recovery than Con (%PCr, 56\u00b16% and end-diastolic pressure, 72\u00b16 mm Hg). An ischemic rise in intracellular magnesium occurred and was atttenuated in preconditioned hearts.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Pre-G levels before ischemia influence but are not the sole determinants of the extent of acidosis during prolonged ischemia and of metabolic and contractile recovery during reperfusion in control and preconditioned hearts.\n          <\/jats:p>","DOI":"10.1161\/01.cir.96.3.975","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"975-983","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Preischemic Glycogen Depletion in the Improvement of Postischemic Metabolic and Contractile Recovery of Ischemia-Preconditioned Rat Hearts"],"prefix":"10.1161","volume":"96","author":[{"given":"Paulo R.","family":"Soares","sequence":"first","affiliation":[{"name":"From the Peter Belfer Laboratory of the Cardiology Division, Department of Medicine (P.R.S., C.P.d.A., G.G., R.G.W.), and the Division of NMR Research, Department of Radiology (V.P.C.), The Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicero P.","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"From the Peter Belfer Laboratory of the Cardiology Division, Department of Medicine (P.R.S., C.P.d.A., G.G., R.G.W.), and the Division of NMR Research, Department of Radiology (V.P.C.), The Johns Hopkins Hospital, Baltimore, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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