{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:55:26Z","timestamp":1779897326388,"version":"3.53.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,8,19]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Adenosine-sensitive ventricular tachycardia (VT) is thought to be due to cAMP-mediated triggered activity. It typically originates from the RVOT and occurs in patients with apparently normal hearts. Using magnetic resonance imaging (MRI), we tested the hypothesis that adenosine-sensitive VT occurs in patients without structural heart disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Fourteen patients (9 women; age, 47\u00b119 years) presented with sustained VT (n=3), repetitive monomorphic VT (n=7), or both (n=4). VT terminated with adenosine in each patient and was sensitive to vagal maneuvers in 9 of 11 and verapamil in 10 of 12. VT originated from the right ventricular outflow tract in 10 patients, the right ventricular apex in 1, and the left ventricular septum in 3. Conventional studies included normal signal-averaged ECGs in 9 of 9, normal right ventricular echocardiography in 10 of 10, and normal left ventriculography and coronary angiography in 6 of 7. In contrast, MRI scans were abnormal in 10 of 14 patients. These abnormalities included focal thinning (6), fatty infiltration (4), and wall motion abnormalities (4) of the right ventricle. The most common site of MRI abnormalities was the right ventricular free wall, but there was a poor correlation between the site of MRI abnormalities and the origin of VT. Among 18 control patients without clinical heart disease, thinning of the right ventricular wall was noted in only 1 patient (patients versus control subjects,\n            <jats:italic>P<\/jats:italic>\n            =.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Patients with idiopathic adenosine-sensitive VT comprise a heterogeneous group as assessed by MRI, with 70% demonstrating mild structural abnormalities. However, it is unlikely that these findings are causally related to tachycardia, and the functional significance of these anatomic abnormalities is uncertain.\n          <\/jats:p>","DOI":"10.1161\/01.cir.96.4.1192","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Adenosine-Sensitive Ventricular Tachycardia"],"prefix":"10.1161","volume":"96","author":[{"given":"Steven M.","family":"Markowitz","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie L.","family":"Litvak","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Ramirez de Arellano","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Markisz","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Stein","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and the Department of Radiology, The New York Hospital\u2013Cornell University Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.68.5.6137291"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90350-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061859"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.73.6.3698245"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.56.1.45"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.79.5.2713978"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1989.tb05035.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.68.6.6640870"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80056-X"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90144-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90188-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.82.6.2242533"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90375-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00539-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90175-1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.suppl_F.7"},{"key":"e_1_3_2_17_2","unstructured":"Blake LM Abbot JA Alla SR Higgins CB Scheinman MM. Sensitivity and specificity of MRI for the diagnosis of right ventricular dysplasia versus right ventricular outflow tract tachycardia. Circulation. 1994;90(suppl I):I-300. Abstract."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90020-5"},{"key":"e_1_3_2_19_2","first-page":"924","volume":"18","year":"1995","unstructured":"Grimm W, Hoffman J, Michalik-Himmelmann R, Maisch B. Magnetic resonance imaging and signal averaged ECG in patients with repetitive monomorphic ventricular tachycardia and otherwise normal electrocardiogram. PACE. 1995;18:924. Abstract.","journal-title":"PACE"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.74.2.3015453"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.2.8425287"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.3.421"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.1.8418999"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.5.1572025"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1499"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.65.2.7053899"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801213180301"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb06971.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90948-3"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90462-8"},{"key":"e_1_3_2_31_2","first-page":"549","volume":"161","year":"1993","unstructured":"Auffermann W, Wichter T, Breithardt G, Joachimsen K, Peters PE. Arrhythmogenic right ventricular disease: MR imaging vs angiography. Am J Radiol. 1993;161:549-555.","journal-title":"Am J Radiol"},{"key":"e_1_3_2_32_2","first-page":"809","volume":"162","year":"1994","unstructured":"Blake LM, Scheinman MM, Higgins CB. MR features of arrhythmic right ventricular dysplasia. Am J Radiol. 1994;162:809-812.","journal-title":"Am J Radiol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.3.715"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80720-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1991.tb02736.x"},{"key":"e_1_3_2_36_2","first-page":"24A","volume":"27","year":"1996","unstructured":"Lerman BB, Stein KM, Markowitz SM. Is the response of catecholamine-dependent ventricular tachycardia to adenosine mechanism specific? J Am Coll Cardiol. 1996;27:24A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90286-5"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.53.3.323"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90836-2"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1989.tb02698.x"},{"key":"e_1_3_2_41_2","first-page":"734","volume":"16","year":"1990","unstructured":"Cruz FE, Cheriex EC, Smeets JL, Atie J, Peres AK, Penn OC, Brugada P, Wellens HJ. Reversibility of tachycardia-induced cardiomyopathy after cure of incessant supraventricular tachycardia. J Am Coll Cardiol. 1990;16:734-744.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90705-4"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90462-V"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.8.2306"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1987.tb06037.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80388-1"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.1.1617780"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.96.4.1192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:21:18Z","timestamp":1715530878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.96.4.1192"}},"subtitle":["Right Ventricular Abnormalities Delineated by Magnetic Resonance Imaging"],"short-title":[],"issued":{"date-parts":[[1997,8,19]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,8,19]]}},"alternative-id":["10.1161\/01.CIR.96.4.1192"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.96.4.1192","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,19]]},"assertion":[{"value":"1996-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}