{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:35:04Z","timestamp":1791106504975,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,9,2]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Implantable cardioverter-defibrillator (ICD) therapy is integral to current therapy for ventricular tachycardia. Patients with an ICD frequently require concomitant antiarrhythmic drug therapy. Despite this, some patients still receive frequent ICD therapies for ventricular tachycardia. Therefore, the purpose of this prospective study was to determine the utility of ablation of ventricular tachycardia in patients with an ICD who experience frequent ICD therapies.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            Twenty-one consecutive patients with frequent ICD therapies despite antiarrhythmic drug therapy were the subjects of this study. The mean age was 69\u00b16 years, and 17 were men. The mean ejection fraction was 0.22\u00b10.08, and all patients had coronary artery disease. During the 36\u00b151 days (range, 4 days to 7 months) preceding the ablation procedures, the patients received 34\u00b155 ICD therapies for the clinical ventricular tachycardia, or a mean of 25\u00b188 ICD therapies per month. The patients underwent radiofrequency ablation of the presumed clinical ventricular tachycardia by inducing the tachycardia and mapping according to endocardial activation, continuous electrical activity, pace mapping, concealed entrainment, or mid-diastolic potentials. Ablation of the clinical arrhythmia was successful in 76% of patients during 1.4\u00b10.6 (range, 1 to 3) ablation procedures and required 12.5\u00b19.2 applications of energy. During 11.8\u00b110.0 months of follow-up, the frequency of ICD therapies per month decreased from 60\u00b180 before successful ablation to 0.1\u00b10.3 ICD therapies per month after ablation (\n            <jats:italic>P<\/jats:italic>\n            =.01). A quality-of-life assessment demonstrated a significant improvement after successful (\n            <jats:italic>P<\/jats:italic>\n            =.02) but not unsuccessful ablation (\n            <jats:italic>P<\/jats:italic>\n            =.9).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Radiofrequency ablation of ventricular tachycardia as adjuvant therapy in patients with coronary artery disease and an ICD has a reasonable success rate, significantly reduces ICD therapies, and appears to be associated with an improved quality of life.\n          <\/jats:p>","DOI":"10.1161\/01.cir.96.5.1525","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1525-1531","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":118,"title":["A Prospective Evaluation of Catheter Ablation of Ventricular Tachycardia as Adjuvant Therapy in Patients With Coronary Artery Disease and an Implantable Cardioverter-Defibrillator"],"prefix":"10.1161","volume":"96","author":[{"given":"S. Adam","family":"Strickberger","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Ching","family":"Man","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile G.","family":"Daoud","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiva","family":"Goyal","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Brinkman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Hasse","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bogun","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley P.","family":"Knight","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Weiss","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Bahu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Morady","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-7-529"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90292-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90310-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90209-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.2.1860200"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.2.8425285"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.4.8403311"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.3.8124795"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Willems S Borggrefe M Shenasa M Chen X Hindricks G Haverkamp W Wietholt D Block M Beithardt G. 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