{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:35:43Z","timestamp":1791012943699,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,10,21]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            It is well known that paroxysmal atrial fibrillation (PAF) often precedes the establishment of chronic atrial fibrillation (CAF). However, there have been no definite methods to predict the transition from PAF to CAF. The purpose of this report was to determine prospectively whether P-wave\u2013triggered signal-averaged ECG (P-SAE) is useful for the prediction of the transition to CAF in patients with PAF.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            One hundred twenty-two consecutive patients with PAF were prospectively followed after P-SAE, echocardiography, and 24-hour Holter monitoring at study entry. The duration (Ad) and root-mean-square voltage for the last 30 ms (LP30) of the filtered P wave were measured in P-SAE. The abnormality of P-SAE for the prediction of transition to CAF was defined as Ad \u2265145 ms and LP30 &lt;3.0 \u03bcV. Twenty-three (19%; group 1) of the patients had the abnormality of P-SAE, whereas the others (group 2) did not. During the follow-up period (mean, 26\u00b112 months), 10 patients (43%) in group 1 acquired CAF, whereas the transition to CAF was observed in only 4 patients (4%) in group 2. Kaplan-Meier analysis revealed that the transition to CAF was significantly observed more often in group 1 than in group 2 (log-rank test,\n            <jats:italic>P<\/jats:italic>\n            &lt;.0001). The Cox proportional hazards regression model identified that the variables most significantly associated with the transition to CAF were Ad (\u03c7\n            <jats:sup>2<\/jats:sup>\n            =8.6,\n            <jats:italic>P<\/jats:italic>\n            =.003) and LP30 (\u03c7\n            <jats:sup>2<\/jats:sup>\n            =5.1,\n            <jats:italic>P<\/jats:italic>\n            =.02), although significant differences in the left atrial dimension (40.8\u00b15.3 versus 37.3\u00b15.5 mm,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) and the number of atrial premature contractions (3641\u00b14524 versus 1489\u00b12895 beats\/d,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05) were observed between groups 1 and 2.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            These results indicate that P-SAE could be useful to identify patients at risk for the transition from PAF to CAF.\n          <\/jats:p>","DOI":"10.1161\/01.cir.96.8.2612","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"2612-2616","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":95,"title":["Prediction of Transition to Chronic Atrial Fibrillation in Patients With Paroxysmal Atrial Fibrillation by Signal- Averaged Electrocardiography"],"prefix":"10.1161","volume":"96","author":[{"given":"Yasushi","family":"Abe","sequence":"first","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatake","family":"Fukunami","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Yamada","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Ohmori","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Shimonagata","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Kumagai","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoong","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Sanada","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Hori","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritake","family":"Hoki","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (Y.A., M.F., T.Y., M.O., T.S., K.K., J.K., S.S., N.H.), Osaka Prefectural Hospital, and The 1st Internal Medicine (M.H.), Osaka University Medical School, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80240-9"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198709103171104"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.22.143"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91015-A"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Peterson P Godtfredsen J. Embolic complications in paroxysmal atrial fibrillation. Stroke. 1986;622-626.","DOI":"10.1161\/01.STR.17.4.622"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(87)80102-9"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310400022019"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","unstructured":"Treseder AS Sastry BSD Thomas TPL Yates MA Pathy MS. Atrial fibrillation and stroke in elderly hospitalized patients. Age Ageing. 15:89-92 1986.","DOI":"10.1093\/ageing\/15.2.89"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1984.tb03763.x"},{"key":"e_1_3_1_10_2","unstructured":"Godtfredsen J. Atrial Fibrillation: Etiology Course and Prognosis: A Follow-up Study of 1212 Cases. Copenhagen Denmark: Munksgaard; 1975."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.1.1984879"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80273-6"},{"key":"e_1_3_1_13_2","unstructured":"Abe Y Fukunami M Ohmori M Kumagai K Yamada T Nishikawa N Hoki N. Prediction of transition from paroxysmal atrial fibrillation by P wave\u2013triggered signal-averaged electrocardiogram. Circulation. 1993;88(suppl II):II-312. Abstract."},{"key":"e_1_3_1_14_2","unstructured":"Feigenbaum H ed. Echocardiography. Philadelphia Pa: Lea & Febiger; 1981."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.31.6.888"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90208-9"},{"key":"e_1_3_1_17_2","unstructured":"Iwakura K Abe Y Ohmori M Yamada T Kondoh N Minamino T Tsujimura E Fukunami M. Relationship between frequency and duration of paroxysmal atrial fibrillation attacks and atrial late potential. Circulation. 1992;86(suppl I):I-130. Abstract."},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204293061703"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90648-5"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90381-A"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.96.8.2612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:31:33Z","timestamp":1715531493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.96.8.2612"}},"subtitle":["A Prospective Study"],"short-title":[],"issued":{"date-parts":[[1997,10,21]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,10,21]]}},"alternative-id":["10.1161\/01.CIR.96.8.2612"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.96.8.2612","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10,21]]},"assertion":[{"value":"1997-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}