{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:18Z","timestamp":1787017998278,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1997,10,21]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    The purpose of the study was to evaluate the effect of AV junction ablation and pacemaker implantation on quality of life and specific symptoms in patients with paroxysmal atrial fibrillation (AF) not controlled by drugs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    We performed a multicenter, randomized, 6-month evaluation of the clinical effects of AV junction ablation and DDDR mode-switching pacemaker (Abl+Pm) versus pharmacological treatment in 43 patients with intolerable, recurrent paroxysmal AF of three or more episodes in the previous 6 months not controlled with three or more antiarrhythmic drugs. Before completion of the study, 3 patients in the drug group withdrew because of the severity of their symptoms and 1 patient assigned to the Abl+Pm group in whom the ablation procedure failed. At the end of the 6 months, the 21 patients of the Abl+Pm group who completed the study showed, in comparison with the 18 of the drug group, lower scores in the Living with Heart Failure Questionnaire (\u221251%,\n                    <jats:italic>P<\/jats:italic>\n                    =.0006), palpitations (\u221271%,\n                    <jats:italic>P<\/jats:italic>\n                    =.0000), effort dyspnea (\u221236%,\n                    <jats:italic>P<\/jats:italic>\n                    =.04), exercise intolerance score (\u221246%,\n                    <jats:italic>P<\/jats:italic>\n                    =.001), and easy fatigue (\u221251%,\n                    <jats:italic>P<\/jats:italic>\n                    =.02). The scores for rest dyspnea, chest discomfort, and NYHA functional classification were also lower (\u221256%, \u221250%, and \u221217%, respectively) in the Abl+Pm group, although not significantly. At the end of the study, palpitations were no longer present in 81% of the Abl+Pm group and in 11% of the drug group (\n                    <jats:italic>P<\/jats:italic>\n                    =.0000). AF was documented in 31 of 122 visits (25%) in the Abl+Pm group and in 9 of 107 examinations (8%) in the drug group (\n                    <jats:italic>P<\/jats:italic>\n                    =.0005); chronic AF developed in 5 (24%) and 0 (0%) in the two groups, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    =.04).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    In patients with paroxysmal AF not controlled by pharmacological therapy, Abl+Pm treatment is highly effective and superior to drug therapy in controlling symptoms and improving quality of life. The discontinuation of drug therapy exposes patients to further recurrences of paroxysmal AF and the risk of developing permanent AF.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.96.8.2617","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:41:02Z","timestamp":1339447262000},"page":"2617-2624","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":186,"title":["Assessment of Atrioventricular Junction Ablation and DDDR Mode-Switching Pacemaker Versus Pharmacological Treatment in Patients With Severely Symptomatic Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"96","author":[{"given":"Michele","family":"Brignole","sequence":"first","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorella","family":"Gianfranchi","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Menozzi","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Alboni","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Musso","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Bongiorni","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Gasparini","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Raviele","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Lolli","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Paparella","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Acquarone","sequence":"additional","affiliation":[{"name":"From the Section of Arrhythmology, Ospedali Riuniti, Lavagna (M.B., L.G.); Department of Cardiology and Arrhythmological Center, Ospedale S Maria Nuova, Reggio Emilia (C.M., G.L.); Department of Cardiology and Arrhythmological Center, Ospedale Civile, Cento (P.A., N.P.); Section of Arrhythmology, Ospedale Civile, Imperia (G.M., S.A.); Institute of Clinical Physiology, Centro Nazionale delle Ricerche, Pisa (M.G.B.); Department of Cardiology, Service of Arrhythmology, Ospedale Niguarda, Milano (M.G.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91214-3"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb06982.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90528-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.7.1585"},{"key":"e_1_3_2_5_2","first-page":"198","volume":"3","year":"1987","unstructured":"Rector TS, Kubo SH, Cohn JN. 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