{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:09:54Z","timestamp":1788390594650,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,4,7]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014In dogs, a large amount of intravenous cocaine causes a profound deterioration of left ventricular (LV) systolic function and an increase in LV end-diastolic pressure. This study was done to assess the influence of a high intracoronary cocaine concentration on LV systolic and diastolic function in humans.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In 20 patients (14 men and 6 women aged 39 to 72 years) referred for cardiac catheterization for the evaluation of chest pain, we measured heart rate, systemic arterial pressure, LV pressure and its first derivative (dP\/dt), and LV volumes and ejection fraction before and during the final 2 to 3 minutes of a 15-minute intracoronary infusion of saline (n=10, control subjects) or cocaine hydrochloride 1 mg\/min (n=10). No variable changed with saline. With cocaine, the drug concentration in blood obtained from the coronary sinus was 3.0\u00b10.4 (mean\u00b1SD) mg\/L, similar in magnitude to the blood cocaine concentration reported in abusers dying of cocaine intoxication. Cocaine induced no significant change in heart rate, LV dP\/dt (positive or negative), or LV end-diastolic volume, but it caused an increase in systolic and mean arterial pressures, LV end-diastolic pressure, and LV end-systolic volume, as well as a decrease in LV ejection fraction.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014In humans, the intracoronary infusion of cocaine sufficient in amount to achieve a high drug concentration in coronary sinus blood causes a deterioration of LV systolic and diastolic performance.\n          <\/jats:p>","DOI":"10.1161\/01.cir.97.13.1270","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1270-1273","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Effects of the Intracoronary Infusion of Cocaine on Left Ventricular Systolic and Diastolic Function in Humans"],"prefix":"10.1161","volume":"97","author":[{"given":"William R.","family":"Pitts","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, and the Cardiac Catheterization Laboratory, Parkland Memorial Hospital, Dallas, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpen","family":"Vongpatanasin","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, and the Cardiac Catheterization Laboratory, Parkland Memorial Hospital, Dallas, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin E.","family":"Cigarroa","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, and the Cardiac Catheterization Laboratory, Parkland Memorial Hospital, Dallas, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. David","family":"Hillis","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, and the Cardiac Catheterization Laboratory, Parkland Memorial Hospital, Dallas, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lange","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, and the Cardiac Catheterization Laboratory, Parkland Memorial Hospital, Dallas, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"309","volume":"28","year":"1989","unstructured":"Abel FL, Wilson SP, Zhao R, Fennell WH. Cocaine depresses the canine myocardium. Circ Shock. 1989;28:309\u2013319.","journal-title":"Circ Shock"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90226-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90301-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.81.3.2306813"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90142-A"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00279-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90559-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90784-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-12-1039"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90580-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960130505"},{"key":"e_1_3_2_12_2","first-page":"900","volume":"115","year":"1991","unstructured":"Escobedo LG, Ruttenber AJ, Agocs MM, Anda RF, Wetli CV. 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