{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:19Z","timestamp":1787017999687,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,5,19]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Quantification of regional myocardial function is a major unresolved issue in cardiology. We evaluated the accuracy of pulsed Doppler tissue imaging (DTI), a new echocardiographic technique, to quantify regional myocardial dysfunction induced by acute ischemia and reperfusion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    \u2014In nine open-chest anesthetized pigs, various degrees of regional wall motion abnormalities were induced by graded reduction of left anterior descending coronary artery (LAD) blood flow. Pulsed Doppler tissue imaging was performed from an epicardial apical four-chamber view with the sample placed within the middle part of the septal wall. Peak septal velocities were calculated during systole, isovolumic relaxation, and early and late diastole. Regional myocardial blood flow and systolic and diastolic dysfunctions were assessed by radioactive microspheres and ultrasonic crystals, respectively. Ischemia resulted in a significant rapid reduction of systolic velocities and an early decrease in the ratio of early to late diastolic velocities. Both changes were detected by pulsed DTI within 5 seconds of coronary artery occlusion. The decrease in systolic velocity significantly correlated with both systolic shortening (\n                    <jats:italic>r<\/jats:italic>\n                    =.90,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.0001) and regional myocardial blood flow (\n                    <jats:italic>r<\/jats:italic>\n                    =.96,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.0001) during reduction of LAD blood flow.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014These results suggest that DTI may be a promising new tool for the quantification of ischemia-induced regional myocardial dysfunction.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.97.19.1970","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:41:02Z","timestamp":1339447262000},"page":"1970-1977","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":233,"title":["Doppler Tissue Imaging Quantitates Regional Wall Motion During Myocardial Ischemia and Reperfusion"],"prefix":"10.1161","volume":"97","author":[{"given":"Genevie\u0300ve","family":"Derumeaux","sequence":"first","affiliation":[{"name":"From the De\u0301partment de Cardiologie, Ho\u0302pital Charles Nicolle, Centre Hospitalier Universitaire de Rouen, and Laboratoire de Physiologie Lyon-Nord et Service de Cardiologie D, Universite\u0301 Claude Bernard (M.O., J.L., X.A.-F., Y.M.), Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ovize","sequence":"additional","affiliation":[{"name":"From the De\u0301partment de Cardiologie, 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