{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:33:17Z","timestamp":1786336397444,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,7,7]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Atrioventricular nodal reentry tachycardia (AVNRT) represents the most commonly encountered type of regular paroxysmal supraventricular tachycardia. This study determined whether administration of adenosine-5\u2032-triphosphate (ATP) during sinus rhythm may be useful in the noninvasive diagnosis of dual AV nodal pathways.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014During electrophysiological study, we intravenously administered incremental doses of ATP (from 10 to 50 mg) during sinus rhythm to patients with spontaneous and inducible sustained AVNRT (study group, n=42) and to patients with no evidence of dual AV nodal physiology or inducible AVNRT (control group, n=21). Signs suggestive of dual AV node physiology after ATP administration during sinus rhythm (\u201cjump\u201d of AH \u226550 ms between 2 consecutive beats, \u22651 AV nodal echo beat, or initiation of AVNRT) were observed in 32 (76%) of 42 study patients but in only 1 (5%) of the 21 control patients (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Similar results were observed when only surface lead recordings (without intracardiac recordings) were evaluated. Signs suggestive of dual AV node physiology by the ATP test were observed in 29 (80.5%) of 36 patients who had electrophysiological demonstration of dual AV node physiology and in 3 (50%) of 6 patients without AV nodal duality (\n            <jats:italic>P<\/jats:italic>\n            =NS). Signs suggestive of dual physiology according to the ATP test disappeared in 11 (92%) of the 12 patients who underwent successful slow AV nodal ablation but persisted in 8 (62%) of 13 patients who underwent AV nodal modification\n            <jats:italic>.<\/jats:italic>\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Administration of ATP during sinus rhythm may be a useful bedside test for identifying patients with dual AV nodal pathways who are prone to AVNRT. This simple test should be considered as a screening test for patients with symptoms suggestive of paroxysmal supraventricular tachycardia but no documented arrhythmias or for patients with documented narrow complex tachycardia of unclear mechanism.\n          <\/jats:p>","DOI":"10.1161\/01.cir.98.1.47","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Noninvasive Diagnosis of Dual AV Node Physiology in Patients With AV Nodal Reentrant Tachycardia by Administration of Adenosine-5\u2032-Triphosphate During Sinus Rhythm"],"prefix":"10.1161","volume":"98","author":[{"given":"Bernard","family":"Belhassen","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Fish","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharon","family":"Glick","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eldar","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Laniado","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Viskin","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Sourasky-Tel-Aviv Medical Center (B.B., R.F., A.G., S.L., S.V.) and Sheba Medical Center (M.G., M.E.), Sackler School of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.68.4.6616776"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.4.3349581"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90376-C"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00011-9"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.37.10.1069"},{"key":"e_1_3_1_6_2","unstructured":"Sung RJ Huycke EC Keung EC Tseng CD Lai WT. Atrioventricular node reentry: evidence of reentry and functional properties of fast and slow pathways. In: Zipes DP Jalife J eds. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia Pa: WB Saunders Co; 1990:513\u2013525."},{"key":"e_1_3_1_7_2","unstructured":"Josephson ME. Clinical Cardiac Electrophysiology: Techniques and Interpretations. 2nd ed. Philadelphia Pa: Lea & Febiger;1993:187."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.5.969"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.4.1201"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90486-W"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90289-5"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.1.54"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.98.1.47","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:20:53Z","timestamp":1715530853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.98.1.47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7,7]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,7,7]]}},"alternative-id":["10.1161\/01.CIR.98.1.47"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.98.1.47","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7,7]]},"assertion":[{"value":"1997-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}