{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:46:51Z","timestamp":1787510811669,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,9,8]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Although coronary artery lesions are critical complications of Kawasaki disease, their long-term outcome is still unclear. It is sometimes difficult to monitor progressive changes from aneurysms to stenotic lesions because coronary angiography (CAG) cannot be repeated very often, especially in infants. Our prospective study was designed to evaluate the prognostic value of dipyridamole-thallium single-photon-emission CT (SPECT) in the long-term follow-up of patients with Kawasaki disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    \u2014Of 459 consecutive patients with Kawasaki disease, coronary aneurysms were detected in 90 cases by echocardiography during the acute stage. After paired studies of selective CAG and SPECT were conducted, all patients were followed up and monitored for the occurrence of any cardiac events for \u22658 years. During the follow-up interval, there were 15 cardiac events (1 death, 5 infarctions, 2 coronary artery bypass graft operations, and 7 occurrences of unstable angina). Of patients who had some event, thallium redistribution was found on SPECT in 14 (93%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). Of the various clinical and scintigraphic image variables, the presence of thallium redistribution was the best multivariate independent predictor of a late cardiac event (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    =57.8,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). The number of aneurysms detected on CAG added minimal statistical improvement to the model (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    =1.9,\n                    <jats:italic>P<\/jats:italic>\n                    =0.0009).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Dipyridamole-thallium SPECT is safely performed and is useful and important for risk stratification in the long-term follow-up of patients with Kawasaki disease.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.98.10.990","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:41:02Z","timestamp":1339447262000},"page":"990-996","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Prognostic Value of Dipyridamole-Thallium Myocardial Scintigraphy in Patients With Kawasaki Disease"],"prefix":"10.1161","volume":"98","author":[{"given":"Masao","family":"Miyagawa","sequence":"first","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhito","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Murase","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Tanada","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Ikezoe","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihito","family":"Sekiya","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Niino","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (M.M.) and the Department of Internal Medicine (M.S.), Ehime National Hospital; the Department of Radiology (T.M., K.M., S.T., J.I.) and the Department of Pediatrics (S.M., M.N.), Ehime University School of Medicine; and the Department of Radiology, the City of Yawatahama Hospital (K.H.), Ehime, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.54.3.271"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.5.8491037"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.2.3802442"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81894-3"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93152-D"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.3.2788529"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.2.2752565"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90166-2"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80390-4"},{"key":"e_1_3_1_10_2","unstructured":"Engelman L. Stepwise logistic regression. In: BMDP Statistical Software Manual. Berkeley Calif: University of California Press; 1988;2:941\u2013969."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150601"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199408000-00005"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.6.1379"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90767-2"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.2.8313588"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.1.122"},{"key":"e_1_3_1_17_2","first-page":"1218","volume":"144","year":"1990","unstructured":"Dajani AS, Bisno AL, Chung KJ, Durack DT, Gerber MA, Kaplan EL, Millard D, Randolph MF, Shulman ST, Taubert KA, Watanakunakorn C. Diagnostic guidelines for Kawasaki disease. Am J Dis Child. 1990;144:1218\u20131219.","journal-title":"Am J Dis Child"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505233122114"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404193101603"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90592-B"},{"key":"e_1_3_1_21_2","first-page":"1839","volume":"28","year":"1987","unstructured":"Spielmann RS, Nienaber CA, Hausdorf G, Montz R. Tomographic myocardial perfusion scintigraphy in children with Kawasaki disease. J Nucl Med. 1987;28:1839\u20131843.","journal-title":"J Nucl Med"},{"key":"e_1_3_1_22_2","unstructured":"Naoe S Takahashi K Masuda H Tanaka N. Coronary findings post Kawasaki disease in children who died of other causes. In: Shulman ST ed. Kawasaki Disease. New York NY: Alan R Liss; 1987:341\u2013346."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00003-M"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00796982"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90167-8"},{"key":"e_1_3_1_26_2","first-page":"454","volume":"96","year":"1997","unstructured":"Mitani Y, Okuda Y, Shimpo H, Uchida F, Hamanaka K, Aoki K, Sakurai M. Impaired endothelial function in epicardial coronary arteries after Kawasaki disease. Circulation. 1997;96:454\u2013461.","journal-title":"Circulation"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.98.10.990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:50:31Z","timestamp":1715518231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.98.10.990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,8]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,9,8]]}},"alternative-id":["10.1161\/01.CIR.98.10.990"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.98.10.990","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,8]]},"assertion":[{"value":"1997-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}