{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:12:11Z","timestamp":1789787531891,"version":"4.0.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,9,29]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014It has been claimed that patients with sick sinus syndrome have an increased risk of developing AV block, but this has never been assessed prospectively. The aim of the present study was to evaluate in a prospective trial AV conduction during the long-term follow-up of patients with sick sinus syndrome.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Two hundred twenty-five consecutive patients with sick sinus syndrome and intact AV conduction were randomized to undergo single-chamber atrial pacing (110 patients) or single-chamber ventricular pacing (115 patients). Follow-up after 3 months and then yearly included measurement of the PQ interval and, in patients with atrial pacemakers, determination of the atrial stimulus\u2013Q intervals at pacing rates of 100 and 120 bpm. The occurrence of AV block in the atrial group was recorded. During follow-up (mean, 5.5\u00b12.4 years), there was no change in PQ interval in either group and no change in atrial stimulus\u2013Q intervals or Wenckebach block point in the atrial group. Four of 110 patients in the atrial group developed grade 2 to 3 AV block that required upgrading of the pacemaker (0.6% per year). Two of these 4 patients had right bundle-branch block at pacemaker implantation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014AV conduction, estimated as PQ interval and atrial stimulus\u2013Q interval at atrial pacing rates of 100 and 120 bpm and the Wenckebach block point, remains stable during long-term follow-up. Thus, treatment with single-chamber atrial pacing is safe and can be recommended to patients with sick sinus syndrome without bundle-branch block.\n          <\/jats:p>","DOI":"10.1161\/01.cir.98.13.1315","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1315-1321","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":95,"title":["Atrioventricular Conduction During Long-Term Follow-Up of Patients With Sick Sinus Syndrome"],"prefix":"10.1161","volume":"98","author":[{"given":"Henning Rud","family":"Andersen","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Cosedis","family":"Nielsen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul Erik Bloch","family":"Thomsen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Thuesen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vesterlund","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Kirstein","family":"Pedersen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Thomas","family":"Mortensen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03425-9"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.10.987"},{"key":"e_1_3_2_3_2","unstructured":"Andersen HR. 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