{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:43:51Z","timestamp":1781916231466,"version":"3.54.5"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,10,6]]},"abstract":"\n Background<\/jats:italic>\n \u2014The management of neonates with complex congenital anomalies depends on careful interpretation of arterial blood gas values. Improved interpretation of these oxygen parameters may allow clinicians to avoid unexpected cardiovascular events. This study examined whether systemic oxygen delivery (D\n o<\/jats:sc>\n 2<\/jats:sub>\n ) can be maximized by the use of indices derived from oxygen saturation measurements in neonates with hypoplastic left heart syndrome.\n <\/jats:p>\n \n Methods and Results<\/jats:italic>\n \u2014For the single-ventricle heart with both circulations in parallel, we used a previously developed computer simulation to obtain D\n o<\/jats:sc>\n 2<\/jats:sub>\n as a function of systemic arterial (Sa\n o<\/jats:sc>\n 2<\/jats:sub>\n ) and venous (Sv\n o<\/jats:sc>\n 2<\/jats:sub>\n ) oxygen saturation, arteriovenous oxygen difference (Sa-v\n o<\/jats:sc>\n 2<\/jats:sub>\n ), or pulmonary-to-systemic flow ratio (Qp\/Qs). We also examined the oxygen excess factor, Sa\n o<\/jats:sc>\n 2<\/jats:sub>\n \/Sa-v\n o<\/jats:sc>\n 2<\/jats:sub>\n (\u03a9). We found that (1) slight increases in Sa\n o<\/jats:sc>\n 2<\/jats:sub>\n may be associated with large decreases in D\n o<\/jats:sc>\n 2<\/jats:sub>\n . (2) Low values for Sv\n o<\/jats:sc>\n 2<\/jats:sub>\n indicate low values for D\n o<\/jats:sc>\n 2<\/jats:sub>\n . (3) Curves for Sa-v\n o<\/jats:sc>\n 2<\/jats:sub>\n and Qp\/Qs are redundant in the data provided. (Qp\/Qs, however, provides these data in more physiologically relevant terms.) (4) High values for Qp\/Qs (>4) are associated with low D\n o<\/jats:sc>\n 2<\/jats:sub>\n . (5) Estimating Qp\/Qs from oxygen saturation measurements may result in errors when pulmonary venous oxygen saturation is not available. (6) Maximizing D\n o<\/jats:sc>\n 2<\/jats:sub>\n is extremely difficult using Sa\n o<\/jats:sc>\n 2<\/jats:sub>\n , Sv\n o<\/jats:sc>\n 2<\/jats:sub>\n , and Qp\/Qs. (7) A linear relationship exists between \u03a9 and D\n o<\/jats:sc>\n 2<\/jats:sub>\n , and this linear relationship is not altered by changes in cardiac output.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n \u2014Patients with low Sv\n o<\/jats:sc>\n 2<\/jats:sub>\n values require attention. Ideally, after reducing Qp\/Qs to <1.5, \u03a9 might be a better index to guide further therapy and maximize D\n o<\/jats:sc>\n 2<\/jats:sub>\n . Interventions that increased \u03a9 would be considered beneficial, whereas interventions that decreased \u03a9 would be considered detrimental.\n <\/jats:p>","DOI":"10.1161\/01.cir.98.14.1407","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:41:02Z","timestamp":1339461662000},"page":"1407-1413","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":116,"title":["Estimation of Oxygen Delivery in Newborns With a Univentricular Circulation"],"prefix":"10.1161","volume":"98","author":[{"given":"Ofer","family":"Barnea","sequence":"first","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Santamore","sequence":"additional","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rossi","sequence":"additional","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis","family":"Salloum","sequence":"additional","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufan","family":"Chien","sequence":"additional","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erle H.","family":"Austin","sequence":"additional","affiliation":[{"name":"From the Biomedical Engineering Department, Tel Aviv University, Israel (O.B.); the Department of Surgery, University of Louisville, Ky (W.P.S., E.S., S.C., E.H.A.); and the Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Norwood WI Jr. Hypoplastic left heart syndrome. In: Sabiston DC ed. Textbook of Surgery. Philadelphia Pa: WB Saunders; 1991:1930\u20131935."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91581-E"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30442-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90123-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90293-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01711904"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198411000-00007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199309000-00022"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08941939609021279"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00297-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81690-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.2.3802439"},{"key":"e_1_3_2_13_2","first-page":"449","volume":"100","year":"1997","unstructured":"Rossi AN, Seiden HS, Gross RP, Griepp RB. Oxygen transport in critically ill infants following heart surgery. Pediatrics.. 1997;100:449\u2013450.","journal-title":"Pediatrics."},{"key":"e_1_3_2_14_2","first-page":"290","volume":"28","year":"1992","unstructured":"Barnea O, Santamore WP. Coronary autoregulation and optimal myocardial oxygen utilization. Basic Res Cardiol.. 1992;28:290\u2013301.","journal-title":"Basic Res Cardiol."},{"key":"e_1_3_2_15_2","first-page":"203","volume":"203","year":"1990","unstructured":"Whyte RK. Mixed venous oxygen saturation in the newborn: can we and should we measure it? Scand J Clin Lab Invest Suppl.. 1990;203:203\u2013211.","journal-title":"Scand J Clin Lab Invest Suppl."},{"key":"e_1_3_2_16_2","first-page":"165","volume":"40","year":"1989","unstructured":"Scheinman MM, Brown MA, Rapaport E. Critical assessment of use of central venous oxygen saturation as a mirror of mixed venous oxygen in severely ill patients. Circulation.. 1989;40:165\u2013172.","journal-title":"Circulation."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.98.14.1407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:54:12Z","timestamp":1715532852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.98.14.1407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10,6]]},"references-count":16,"journal-issue":{"issue":"14","published-print":{"date-parts":[[1998,10,6]]}},"alternative-id":["10.1161\/01.CIR.98.14.1407"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.98.14.1407","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10,6]]},"assertion":[{"value":"1998-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}