{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:40:13Z","timestamp":1792716013315,"version":"4.5.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1998,7,21]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Conflicting evidence exists concerning whether insulin-induced vasodilation plays a mechanistic role in the regulation of limb glucose uptake. It can be predicted that if insulin augments blood flow by causing tissue recruitment, this mechanism would enhance limb glucose uptake.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    \u2014Twenty healthy subjects were studied with the forearm perfusion technique in combination with the euglycemic insulin clamp technique. Ten subjects were studied at physiological insulin concentrations (\u2248400 pmol\/L) and the other 10 at supraphysiological insulin concentrations (\u22485600 pmol\/L). Four additional subjects underwent a saline control study. Pulse injections of a nonmetabolizable extracellular marker (1-[\n                    <jats:sup>3<\/jats:sup>\n                    H]-\n                    <jats:sc>l<\/jats:sc>\n                    -glucose) were administered into the brachial artery, and its washout curves were measured in one ipsilateral deep forearm vein and used to estimate the extracellular volume of distribution and hence the amount of muscle tissue drained by the deep forearm vein. Both during saline infusion and at physiological levels of hyperinsulinemia we observed no changes in blood flow and\/or muscle tissue drained by the deep forearm vein. However, supraphysiological hyperinsulinemia accelerated total forearm blood flow (45.0\u00b11.8 versus 36.5\u00b11.3 mL \u00b7 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7 kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01) and increased the amount of muscle tissue drained by the deep forearm vein (305\u00b146 versus 229\u00b132 g,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). The amount of tissue newly recruited by insulin was strongly correlated to the concomitant increase in tissue glucose uptake (\n                    <jats:italic>r<\/jats:italic>\n                    =0.789,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Acceleration of forearm blood flow mediated by supraphysiological hyperinsulinemia is accompanied by tissue recruitment, which may be a relevant determinant of forearm (muscle) glucose uptake.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.98.3.234","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:41:02Z","timestamp":1339447262000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":110,"title":["Role of Tissue-Specific Blood Flow and Tissue Recruitment in Insulin-Mediated Glucose Uptake of Human Skeletal Muscle"],"prefix":"10.1161","volume":"98","author":[{"given":"Riccardo C.","family":"Bonadonna","sequence":"first","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. Murphy Veterans Administration Hospital, San Antonio, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Saccomani","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. Murphy Veterans Administration Hospital, San Antonio, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Prato","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. Murphy Veterans Administration Hospital, San Antonio, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Bonora","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. Murphy Veterans Administration Hospital, San Antonio, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A.","family":"DeFronzo","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. Murphy Veterans Administration Hospital, San Antonio, Tex."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cobelli","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology and Metabolic Diseases (R.C.B., E.B.), University of Verona and Azienda Ospedaliera di Verona (Italy); the Department of Electronics and Informatics (M.P.S., C.C.) and the Division of Metabolic Diseases (S.D.P.), University of Padua (Italy); and the Division of Diabetes (R.A.D.), University of Texas Health Science Center and Audie L. 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Insulin increases blood volume in human skeletal muscle: studies using [15O]CO and positron emission tomography. Am J Physiol. 1995;269:E1000\u2013E1005.","journal-title":". Am J Physiol"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402539"},{"key":"e_1_3_2_44_2","first-page":"H568","volume":"253","year":"1986","unstructured":"Meyer J-U, Lindbom L, Intaglietta M. Coordinated diameter oscillations at arteriolar bifurcations in skeletal muscle. 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