{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:31:12Z","timestamp":1789201872488,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,1,12]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Longitudinal dissociation of an anatomic pathway into 2 electrophysiologically distinct pathways has been hypothesized as a basis for localized AV nodal reentry and supraventricular arrhythmias.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Extracellular bipolar and intracellular microelectrodes were used to record activation in the superfused rabbit AV junction. A subset of rabbit hearts (n=19 of 72) demonstrated dissociation of the posterior AV nodal input into \u22652 functional pathways. Antegrade AH conduction was maintained by a pathway just inferior to the tendon of Todaro. Rate-dependent conduction block was observed in a second pathway just superior to the tricuspid annulus, allowing retrograde activation of the distal portion of the inferior posterior AV nodal input and leading to the formation of apparent \u201cdead-end\u201d pathways. The superior (antegrade) and inferior (retrograde) pathways were separated by a band of well-polarized but poorly excitable transitional cells. Additional decreases in the atrial cycle length progressively increased the AH interval, further delaying retrograde activation of the inferior pathway, and progressively moved the site of conduction block in the inferior pathway proximally, thus extending the length of the retrograde conduction pathway and allowing circus movement within the transitional cells of the posterior AV nodal connection.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Longitudinal dissociation within the posterior AV nodal input can give rise to localized reentry and AV nodal reentrant tachycardia.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.1.143","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"143-155","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Longitudinal Dissociation Within the Posterior AV Nodal Input of the Rabbit"],"prefix":"10.1161","volume":"99","author":[{"given":"Eugene","family":"Patterson","sequence":"first","affiliation":[{"name":"From the Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center (B.J.S., E.P.) and Department of Veterans Affairs Medical Center (B.J.S., E.P.), Oklahoma City, Okla."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Scherlag","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center (B.J.S., E.P.) and Department of Veterans Affairs Medical Center (B.J.S., E.P.), Oklahoma City, Okla."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.48.3.549"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.36.6.1132071"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.4.4.357"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.19.2.378"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.28.4.403"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.43.6.862"},{"key":"e_1_3_2_7_2","first-page":"179","volume":"201","year":"1988","unstructured":"Mazgalev T, Dreifus LS, Bianchi J, Michelson EL. The mechanism of AV junctional reentry: role of the atrionodal junction. Anat Rec. 1988;201:179\u2013188.","journal-title":"Anat Rec"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80273-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270504"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.6.1591833"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.5.1572026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.7.1.11"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.31.4.602"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.35.6.909"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(65)90364-9"},{"key":"e_1_3_2_16_2","unstructured":"Tawara S. Das Reizleitungssytem des saugetier Herzens. Jena Germany: Gustav Fischer; 1906."},{"key":"e_1_3_2_17_2","first-page":"13","volume":"21","year":"1995","unstructured":"Scherlag BJ, Patterson E, Nakagawa H, Hirao K, Jackman WM, Lazzara R. Changing concepts of A-V nodal conduction: basic and clinical correlates. Prim Cardiol. 1995;21:13\u201324.","journal-title":"Prim Cardiol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.4.8462160"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092240303"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.20.6.638"},{"key":"e_1_3_2_21_2","unstructured":"Jackman WM Nakagawa H Heidbuchel H Beckman K McClelland J Lazzara R. Three forms of atrioventricular nodal (junctional) tachycardia. In: Zipes DP Jalife J eds. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia Pa: WB Saunders Co; 1995."},{"key":"e_1_3_2_22_2","first-page":"903A","volume":"21","year":"1998","unstructured":"Patterson E, Scherlag BJ. Differential excitation patterns producing sustained slow-slow, slow-fast, and fast-slow patterns of AV nodal reentrant tachycardia in the rabbit. Pacing Clin Electrophysiol. 1998;21:903A. Abstract.","journal-title":"Pacing Clin Electrophysiol"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.99.1.143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:57:08Z","timestamp":1715533028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.99.1.143"}},"subtitle":["A Substrate for AV Nodal Reentry"],"short-title":[],"issued":{"date-parts":[[1999,1,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1,12]]}},"alternative-id":["10.1161\/01.CIR.99.1.143"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.99.1.143","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,12]]},"assertion":[{"value":"1998-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}