{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:50:51Z","timestamp":1791262251887,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,1,12]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The transmural extent of myocardial necrosis after an acute coronary artery occlusion can vary considerably. The contribution of residual subepicardial viable myocardium to global left ventricular function is largely unknown.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014We studied 12 patients with single-vessel disease 1 week after successful reperfusion of a first transmural anterior myocardial infarction (MI). With PET, myocardial blood flow (MBF) and glucose metabolism were measured regionally, and the viability was graded as normal, mismatch, or match with severely (&lt;50% of normal) or intermediately (50% to 80% of normal) impaired MBF. Magnetic resonance tagging was used to regionally quantify fiber strains, wall thickening, and ejection fraction in patients 1 week and 3 months after the MI and in age-matched healthy volunteers. From 1 week to 3 months, subepicardial fiber shortening improved significantly in the match region (MBF &lt;50%, \u22125.1\u00b17.0% to \u22129.9\u00b18.7%; MBF of 50% to 80%, \u22127.1\u00b17.6% to \u221214.9\u00b17.9%). This was associated with an improvement in regional ejection fraction in the infarcted myocardium (29.6\u00b121.8% to 43.5\u00b115.5%,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) and in normal regions (54.3\u00b115.1% to 56.5\u00b113.1%,\n            <jats:italic>P<\/jats:italic>\n            =0.013), contributing to an increase in global ejection fraction from 44.2\u00b122.2% to 49.3\u00b117.9% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Functional recovery of viable subepicardial regions is a mechanism of late improvement in regional and global ejection fraction after a so-called transmural MI.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.1.36","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Functional Recovery of Subepicardial Myocardial Tissue in Transmural Myocardial Infarction After Successful Reperfusion"],"prefix":"10.1161","volume":"99","author":[{"given":"Jan","family":"Bogaert","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Maes","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Van de Werf","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Bosmans","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Herregods","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Nuyts","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Desmet","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mortelmans","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Marchal","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"Rademakers","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (J.B., H.B., G.M.), Nuclear Medicine (A.M., J.N., L.M.), and Cardiology (F.V.d.W., M.-C.H., W.D., F.E.R.), Gasthuisberg University Hospital, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","first-page":"111","volume":"92","year":"1978","unstructured":"Factor SM, Sonnenblick EH, Kirk ES. 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