{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:06:36Z","timestamp":1790867196060,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,5,11]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Ticlopidine has been shown to reduce the incidence of stent thrombosis compared with warfarin, but it may cause serious hematological side effects. Clopidogrel, a new thienopyridine derivative, may be a safe alternative to ticlopidine. The aim of this study was to compare the safety and efficacy of clopidogrel and aspirin with those of ticlopidine and aspirin in patients undergoing coronary stent implantation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014The population of this study consisted of 2 groups: patients who underwent coronary stenting and were treated with ticlopidine and aspirin (TA group, n=1406), and patients who underwent coronary stenting followed by treatment with clopidogrel and aspirin (CA group, n=283). At 1-month follow-up, there was no difference in stent thrombosis (1.5% versus 1.4%,\n            <jats:italic>P<\/jats:italic>\n            =1.0) or major adverse cardiac events (3.1% versus 2.4%,\n            <jats:italic>P<\/jats:italic>\n            =0.85) between the TA and CA groups, respectively. The probability of any side effect (neutropenia, diarrhea, rash) was significantly higher in the TA group (10.6% versus 5.3%,\n            <jats:italic>P<\/jats:italic>\n            =0.006; relative risk, 0.53; CI, 0.32 to 0.86).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014These data suggest that clopidogrel may be an effective pharmacological regimen after coronary stent implantation. Furthermore, the simpler dosing regimen, the absence of neutropenia, and the lower frequency of other side effects make it a safe alternative to ticlopidine.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.18.2364","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2364-2366","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":261,"title":["Effectiveness of Clopidogrel and Aspirin Versus Ticlopidine and Aspirin in Preventing Stent Thrombosis After Coronary Stent Implantation"],"prefix":"10.1161","volume":"99","author":[{"given":"Issam","family":"Moussa","sequence":"first","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Oetgen","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Roubin","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Iyer","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Maida","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Collins","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Kreps","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[{"name":"From Lenox Hill Hospital, New York, NY, and Centro Cuore Columbus, Milan, Italy (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310802"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1676"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341702"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392303"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Moloney BA. An analysis of the side-effects of ticlopidine. In: Hass WK Easton JD eds. Ticlopidine Platelets and Vascular Disease. New York NY: Springer-Verlag; 1993:117\u2013139.","DOI":"10.1007\/978-1-4613-8306-2_9"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-7-199804010-00004"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_3_1_8_2","unstructured":"Berger P Melby S Grill D Bell M. How long should ticlopidine be administered to intracoronary stent patients not treated with coumadin? Circulation. 1996;94(suppl I):I-256. Abstract."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.12.4.1558834"},{"key":"e_1_3_1_10_2","unstructured":"Makkar R Eigler N Kaul S Zeng H Herbert JM Litvack F. Clopidogrel a novel platelet ADP receptor antagonist inhibits aspirin and ticlopidine resistant stent thrombosis. J Am Coll Cardiol. 1997;29(suppl A):353A. Abstract."},{"key":"e_1_3_1_11_2","first-page":"263","volume":"17","year":"1996","unstructured":"Bachmann F, Savcic M, Hauert J, Geudelin B, Kieffer G, Cariou R. Rapid onset of inhibition of ADP-induced platelet aggregation by a loading dose of clopidogrel. Eur Heart J. 1996;17:263. Abstract.","journal-title":"Eur Heart J"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.11.1046"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.99.18.2364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:27:24Z","timestamp":1715531244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.99.18.2364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,11]]},"references-count":12,"journal-issue":{"issue":"18","published-print":{"date-parts":[[1999,5,11]]}},"alternative-id":["10.1161\/01.CIR.99.18.2364"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.99.18.2364","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5,11]]},"assertion":[{"value":"1998-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}