{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:25:15Z","timestamp":1770071115718,"version":"3.49.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,2,16]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Clinical data and DSE results were analyzed in 1734 consecutive patients undergoing DSE between 1989 and 1997. Seventy-four patients who underwent revascularization within 3 months of DSE and 1 patient lost to follow-up were excluded; the remaining 1659 (median age, 62 years; range, 14 to 99 years) were followed up for 36 months (range, 6 to 96 months). Wall motion abnormalities at rest and the presence and extent of stress-induced wall motion abnormalities (ischemia) were scored for each patient. Cardiac events were related to clinical and ECG data and DSE results. Four hundred twenty-eight cardiac events occurred in 366, documented cardiac death in 108 (total death, 247), nonfatal infarction in 128, and late revascularization in 192 patients. In a multivariable Cox proportional-hazards model, the ratio of documented cardiac death or (re)infarction was increased in the presence of stress-induced ischemia (hazard ratio, 3.3; 95% CI, 2.4 to 4.4) and extensive rest wall motion abnormalities (hazard ratio, 1.9; 95% CI, 1.3 to 2.6). The number of ischemic segments was predictive for late cardiac events. A normal DSE carried a relatively good prognosis, with an annual event rate of cardiac death or infarction of 1.3% over a 5-year period.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014In a large group of patients, DSE has an added value for predicting late cardiac events during long-term follow-up, improving the separation between high- risk and very-low-risk patients.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.6.757","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"757-762","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":124,"title":["Long-Term Prognostic Value of Dobutamine-Atropine Stress Echocardiography in 1737 Patients With Known or Suspected Coronary Artery Disease"],"prefix":"10.1161","volume":"99","author":[{"given":"Don","family":"Poldermans","sequence":"first","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo M.","family":"Fioretti","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"Thomson","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos R. T. C.","family":"Roelandt","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten L.","family":"Simoons","sequence":"additional","affiliation":[{"name":"From the Erasmus University, Rotterdam, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90324-G"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00240-5"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00484-6"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00393-2"},{"key":"e_1_3_1_5_2","first-page":"479","volume":"56","year":"1981","unstructured":"Edwards WD, Tajik AJ, Seward JB. Standardized nomenclature and anatomic basis for regional tomographic analysis of the heart. Mayo Clin Proc. 1981;56:479\u2013497.","journal-title":"Mayo Clin Proc"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(89)80041-0"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90819-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90495-3"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.49.3.489"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.2.1991361"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90669-R"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.5.1110"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90373-9"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91004-2"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90021-3"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00032-6"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.1.137"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90508-8"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00483-1"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.10.3745"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.99.6.757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:27:26Z","timestamp":1715531246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.99.6.757"}},"subtitle":["A Single-Center Experience"],"short-title":[],"issued":{"date-parts":[[1999,2,16]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,2,16]]}},"alternative-id":["10.1161\/01.CIR.99.6.757"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.99.6.757","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,16]]},"assertion":[{"value":"1998-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}