{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:36:30Z","timestamp":1791898590505,"version":"4.3.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,2,16]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The analysis of wall motion abnormalities with dobutamine stress echocardiography (DSE) is an established method for the detection of myocardial ischemia. With ultrafast magnetic resonance tomography, identical stress protocols as used for echocardiography can be applied.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In 208 consecutive patients (147 men, 61 women) with suspected coronary artery disease, DSE with harmonic imaging and dobutamine stress magnetic resonance (DSMR) (1.5 T) were performed before cardiac catheterization. DSMR images were acquired during short breath-holds in 3 short-axis views and a 4- and a 2-chamber view (gradient echo technique). Patients were examined at rest and during a standard dobutamine-atropine scheme until submaximal heart rate was reached. Regional wall motion was assessed in a 16-segment model. Significant coronary heart disease was defined as \u226550% diameter stenosis. Eighteen patients could not be examined by DSMR (claustrophobia 11 and adipositas 6) and 18 patients by DSE (poor image quality). Four patients did not reach target heart rate. In 107 patients, coronary artery disease was found. With DSMR, sensitivity was increased from 74.3% to 86.2% and specificity from 69.8% to 85.7% (both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) compared with DSE. Analysis for women yielded similar results.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014High-dose dobutamine magnetic resonance tomography can be performed with a standard dobutamine\/atropine stress protocol. Detection of wall motion abnormalities by DSMR yields a significantly higher diagnostic accuracy in comparison to DSE.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.6.763","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":609,"title":["Noninvasive Diagnosis of Ischemia-Induced Wall Motion Abnormalities With the Use of High-Dose Dobutamine Stress MRI"],"prefix":"10.1161","volume":"99","author":[{"given":"Eike","family":"Nagel","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans B.","family":"Lehmkuhl","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bocksch","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Vogel","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Frantz","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Ellmer","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dreysse","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Fleck","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, German Heart Institute and Charite\u0301 Campus Virchow, Humboldt University, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80177-6"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00206-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.15.1474"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00121-F"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90508-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.1.8319327"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00483-1"},{"key":"e_1_3_2_8_2","first-page":"425","volume":"167","year":"1987","unstructured":"Sechtem U, Pflugfelder PW, Gould RG, Cassidy MM, Higgins CB. Measurement of right and left ventricular volumes in healthy individuals with cine MR imaging. Radiology. 1987;167:425\u2013430.","journal-title":"Radiology"},{"key":"e_1_3_2_9_2","first-page":"255","volume":"7","year":"1991","unstructured":"Reichek N. Magnetic resonance imaging for assessment of myocardial function. Magn Reson Q. 1991;7:255\u2013274.","journal-title":"Magn Reson Q"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.1.1617775"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(89)80014-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91386-I"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060479"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.1.8025988"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00586-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00195-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb06741.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070328"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"Yang P Kerr A Liu A Liang DH Hardy C Meyer C Macovski A Pauly J Hu B. New real-time interactive cardiac magnetic resonance imaging system. J Am Coll Cardiol. 1998;31(suppl A):3A. Abstract.","DOI":"10.1016\/S0735-1097(98)80682-7"},{"key":"e_1_3_2_20_2","unstructured":"Stuber M Scheidegger MB Boesiger P. Realtime imaging of the heart. Proceedings of the ISMRM. Vancouver Canada: 1997;908. Abstract."},{"key":"e_1_3_2_21_2","unstructured":"Lorenz CH Fischer SE Mens G Johansson LO van Vaals JJ. Interactive cardiac scan planning on a standard clinical MR scanner. Proceedings of the ISMRM. Sydney Australia: 1998;1958. Abstract."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Franke A Hoffmann R K\u00fchl HP Breithardt OA Frieske R Lepper W Hanrath P. Second harmonic imaging without left heart contrast agents improves wall motion analysis and reduces interobserver variability in stress echocardiography. J Am Coll Cardiol. 1998;31(suppl A):76A. Abstract.","DOI":"10.1016\/S0735-1097(98)80979-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"Chin D Hancock J Brown A Prasan A Monaghan M. Improved endocardial definition and evaluation of dobutamine stress echocardiography using second harmonic imaging. J Am Coll Cardiol. 1998;31(suppl A):76A. Abstract.","DOI":"10.1016\/S0735-1097(98)80978-9"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00022-8"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.99.6.763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:27:09Z","timestamp":1715531229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.99.6.763"}},"subtitle":["Comparison With Dobutamine Stress Echocardiography"],"short-title":[],"issued":{"date-parts":[[1999,2,16]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,2,16]]}},"alternative-id":["10.1161\/01.CIR.99.6.763"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.99.6.763","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,16]]},"assertion":[{"value":"1998-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}