{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:23:46Z","timestamp":1775327026208,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,3,9]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014\n            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n            has been hypothesized to play a role in atherothrombosis. However, prospective data relating exposure to\n            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n            and risks of future myocardial infarction (MI) are sparse.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In a prospective cohort of nearly 15 000 healthy men, we measured IgG antibodies directed against\n            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n            in blood samples collected at baseline from 343 study participants who subsequently reported a first MI and from an equal number of age- and smoking-matched control subjects who did not report vascular disease during a 12-year follow-up period. The proportion of study subjects with IgG antibodies directed against\n            <jats:italic>Chlamydia<\/jats:italic>\n            increased with age and cigarette consumption. However, prevalence rates of\n            <jats:italic>Chlamydia<\/jats:italic>\n            IgG seropositivity were virtually identical at baseline among men who subsequently reported first MI compared with age- and smoking-matched control subjects. Specifically, the relative risks of future MI associated with\n            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n            IgG titers \u22651:16, 1:32, 1:64, 1:128, and 1:256 were 1.1, 1.0, 1.1, 1.0, and 0.8, respectively (all probability values not significant). There was no association in analyses adjusted for other risk factors, evaluating early as compared with late events, or among nonsmokers. Further, there was no association between seropositivity and concentration of C-reactive protein, a marker of inflammation that predicts MI risk in this cohort.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014In a large-scale study of socioeconomically homogeneous men that controlled for age, smoking, and other cardiovascular risk factors, we found no evidence of association between\n            <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n            IgG seropositivity and risks of future MI.\n          <\/jats:p>","DOI":"10.1161\/01.cir.99.9.1161","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1161-1164","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":135,"title":["Prospective Study of\n            <i>Chlamydia pneumoniae<\/i>\n            IgG Seropositivity and Risks of Future Myocardial Infarction"],"prefix":"10.1161","volume":"99","author":[{"given":"Paul M.","family":"Ridker","sequence":"first","affiliation":[{"name":"From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens\u2019 Hospital, Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth B.","family":"Kundsin","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens\u2019 Hospital, Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meir J.","family":"Stampfer","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens\u2019 Hospital, Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Poulin","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens\u2019 Hospital, Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Hennekens","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiology (P.M.R.), Preventive Medicine (P.M.R., C.H.H.), Channing Laboratory (M.J.S.), and Microbiology (R.K., S.P.), Department of Medicine, Brigham and Womens\u2019 Hospital, Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90741-6"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490010070032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.4.8484830"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90332-J"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.11.3.2029495"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(95)80006-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.4.841"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.2.585"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.11.2766-2769.1996"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-12-199612150-00008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00055-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.4.8484831"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960201008"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-4-273"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014934"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03079-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.17.1671"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210301"},{"key":"e_1_3_2_20_2","unstructured":"Wang SP Grayston JT. 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