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This effect was dose-dependently reversed by cotreatment with A-779 (selective Ang-[1-7] receptor antagonist) or EXP 3174 (angiotensin type 1 receptor antagonist) but not by PD 123,319 (angiotensin type 2 receptor antagonist). Similarly, the antithrombotic effects of captopril (ACE inhibitor) and losartan (angiotensin type 1 receptor blocker) were attenuated by A-779 in a dose-dependent manner. The effect of Ang-(1-7) was completely abolished by concomitant administration of NO synthase inhibitor (\n            <jats:italic>N<\/jats:italic>\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methyl ester) and prostacyclin synthesis inhibitor (indomethacin), as has been shown previously for captopril and losartan. Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)\u2013evoked release of NO and prostacyclin.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000035396.27909.40","type":"journal-article","created":{"date-parts":[[2002,10,31]],"date-time":"2002-10-31T22:49:12Z","timestamp":1036104552000},"page":"774-779","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":101,"title":["Antithrombotic Effect of Captopril and Losartan Is Mediated by Angiotensin-(1-7)"],"prefix":"10.1161","volume":"40","author":[{"given":"Iwona","family":"Kucharewicz","sequence":"first","affiliation":[{"name":"From the Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pawlak","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Matys","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Pawlak","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wlodzimierz","family":"Buczko","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.87.6.8389259"},{"key":"e_1_3_2_2_2","first-page":"205","volume":"45","year":"1993","unstructured":"Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD. 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