{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:08:53Z","timestamp":1761674933639},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n            We have recently reported that endothelin-1 (ET-1), which is increased in the arteries of deoxycorticosterone acetate (DOCA)\u2013salt hypertensive rats, stimulates superoxide production. However, the humoral mechanisms responsible for ET-1\u2013induced superoxide formation in low-renin models of hypertension, such as DOCA-salt hypertension, remain undefined. Vasopressin is known to upregulate vascular preproET-1 gene expression in DOCA-salt rats, an effect that is absent in vasopressin-deficient Brattleboro rats treated with DOCA-salt. The present study tested the hypothesis that vasopressin contributes to ET-1\u2013induced vascular superoxide production in DOCA-salt hypertensive rats. Carotid arterial segments of DOCA, sham (uninephrectomized), or normal (untreated) rats were used for the study. In vitro vasopressin treatment of carotid arteries from normal rats for 24 hours, but not 4 hours, increased both ET-1 and superoxide levels. The increase of vasopressin-induced superoxide was reduced by pretreatment of the vessels with ABT627, a selective ET\n            <jats:sub>A<\/jats:sub>\n            receptor antagonist ABT627. Vasopressin, ET-1, and superoxide levels were significant elevated in carotid arteries of DOCA-salt rats compared with sham controls. The selective V1-vasopressin receptor antagonist (\u03b2-Mercapto-\u03b2, \u03b2-cyclopentamethylenepropiony\n            <jats:sup>1<\/jats:sup>\n            , O-Me-Tyr\n            <jats:sup>2<\/jats:sup>\n            , Arg\n            <jats:sup>8<\/jats:sup>\n            vasopressin, ME-AVP), decreased superoxide both in vasopressin-treated vessels of normal rats and in vessels of DOCA-salt rats, with a concomitant reduction of ET-1 content. These results suggest that vasopressin increases vascular superoxide levels by stimulating ET-1 formation in mineralocorticoid hypertension, and that V1-vasopressin receptors play an important role in this process.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000047875.43777.79","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T21:45:38Z","timestamp":1046987138000},"page":"663-668","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Vasopressin Induces Vascular Superoxide Via Endothelin-1 in Mineralocorticoid Hypertension"],"prefix":"10.1161","volume":"41","author":[{"given":"Lixin","family":"Li","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, and the Neuroscience Program, Michigan State University, East Lansing."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Galligan","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, and the Neuroscience Program, Michigan State University, East Lansing."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Fink","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, and the Neuroscience Program, Michigan State University, East Lansing."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex F.","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Toxicology, and the Neuroscience Program, Michigan State University, East Lansing."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.87.10.840"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.14.1722"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.37.1.77"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116491"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.74.6.8187280"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14483"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.22.2.249"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112371"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.85.6.562"},{"key":"e_1_3_2_10_2","unstructured":"Li LX Fink GD Watts SW Northcott CA Galligan JJ Pagano PJ Chen AF. ET-1 increases vascular superoxide via ETA-NADPH oxidase pathway in low renin hypertension. Circulation. 2003. In press."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.36.2.234807"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.19.6.753"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.34.4.907"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.32.4.770"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/357333a0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41863-1"},{"key":"e_1_3_2_17_2","first-page":"F41","volume":"253","year":"1987","unstructured":"Jard S, Lombard C, Marie J, Devilliers G. Vasopressin receptors from cultured mesangial cells resemble V1A type. Am J Physiol. 1987; 253: F41\u2013F49.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199712000-00010"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00324-6"},{"key":"e_1_3_2_20_2","first-page":"1006","volume":"14","year":"1978","unstructured":"Butlen D, Guillon G, Rajerison RM, Jard S, Sawyer WH, Manning M. Structural requirements for activation of vasopressin-sensitive adenylate cyclase, hormone binding, and antidiuretic actions: effects of highly potent analogues and competitive inhibitors. Mol Pharmacol. 1978; 14: 1006\u20131017.","journal-title":"Mol Pharmacol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08384.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.6.737"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.6.1214"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199505000-00023"},{"key":"e_1_3_2_25_2","first-page":"447","volume":"132","year":"2001","unstructured":"Yu M, Gopalakrishnan V, McNeill JR. Role of endothelin and vasopressin in DOCA-salt hypertension. Br J Pharmacol. 2001; 132: 447\u2013454.","journal-title":"Br J Pharmacol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054356"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(99)00094-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.6.H2511"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91625-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)90120-1"},{"key":"e_1_3_2_31_2","first-page":"2691","volume":"28","year":"1995","unstructured":"Klemm P, Warner TD, Hohlfeld T, Corder R, Vane JR. Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc Natl Acad Sci U S A. 1995; 28: 2691\u20132695.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0620143"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198504000-00007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1267"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000047875.43777.79","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:51:47Z","timestamp":1715532707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000047875.43777.79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1161\/01.HYP.0000047875.43777.79"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000047875.43777.79","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]},"assertion":[{"value":"2002-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}