{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:41:15Z","timestamp":1770277275456,"version":"3.49.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>\n            We investigated the relation between morning blood pressure (BP) variations, sympathetic activity, and QT intervals in 156 never-treated subjects with essential hypertension and different patterns of morning BP increase. The morning BP peak (MP) was defined as a rise in systolic BP \u226550 mm Hg and\/or diastolic BP \u226522 mm Hg during early morning (6:00 to 10:00\n            <jats:sc>am<\/jats:sc>\n            ) compared with mean BP during the night. Clinical characteristics of patients with morning BP peak (MP+, n= 69, morning systolic BP=+54\u00b14, diastolic BP=+32\u00b15 mm Hg) did not differ from patients without BP peak (MP\u2212, n= 87, morning systolic BP=+24\u00b15, diastolic BP=+19\u00b13 mm Hg). The daytime (10:00\n            <jats:sc>am<\/jats:sc>\n            to 10:00\n            <jats:sc>pm<\/jats:sc>\n            ) and the nighttime (10:00\n            <jats:sc>pm<\/jats:sc>\n            to 6:00\n            <jats:sc>am<\/jats:sc>\n            ) BP profile did not differ between the two groups. During daytime and nighttime ECG monitoring, the corrected QT (QTc) interval, and QTc dispersion did not differ significantly between the two groups, whereas during the morning period the QT values were significantly broader in the MP+ group compared with the MP\u2212 group (\n            <jats:italic>P<\/jats:italic>\n            \u22640.001). Morning LF\/HF ratio was significantly higher in MP+ patients than in MP\u2212 patients (\n            <jats:italic>P<\/jats:italic>\n            \u22640.02). Both systolic and diastolic morning BP, in combination with ratio LF\/HF power, were significant predictors of QTc dispersion (adjusted\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            =0.59,\n            <jats:italic>P<\/jats:italic>\n            \u22640.01) and QTc interval (adjusted\n            <jats:italic>R<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            =0.41,\n            <jats:italic>P<\/jats:italic>\n            \u22640.01), whereas inclusion of physical activity and echocardiographic parameters did not add explanatory information. The prolongation of cardiac repolarization times and morning sympathetic overactivity coexist in hypertensive patients with morning BP peaks, and they might contribute to raised cardiovascular risk in these patients.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000050651.96345.0e","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T23:43:13Z","timestamp":1044574993000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Morning Blood Pressure Peak, QT Intervals, and Sympathetic Activity in Hypertensive Patients"],"prefix":"10.1161","volume":"41","author":[{"given":"Raffaele","family":"Marfella","sequence":"first","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Gualdiero","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Siniscalchi","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Carusone","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Verza","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Marzano","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Esposito","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Giugliano","sequence":"additional","affiliation":[{"name":"From the Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.5.1572037"},{"key":"e_1_3_1_2_2","first-page":"267","volume":"80","year":"1998","unstructured":"Hjalmarson A, Gilpin EA, Nicod P, Dittrich H, Henning H, Blacky AR, Smith SC Jr, Ricou F, Ross J Jr. Differing circadian patterns of symptom onset in subgroups of patients with acute myocardial infarction. 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