{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T08:50:57Z","timestamp":1794646257366,"version":"4.9.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>\n            Peroxisome proliferator\u2013activated receptor-\u03b3 coactivator-1 (PPARGC1\/PGC-1) is a transcriptional coactivator of nuclear hormone receptors implicated in blood pressure regulation. We therefore ascertained whether the\n            <jats:italic>PPARGC1<\/jats:italic>\n            gene locus is associated with hypertension. We studied associations of 3 polymorphisms in PPARGC1 transcripts with hypertension in 683 middle-aged men and 530 middle-aged women of a cross-sectional Austrian population. Hypertension was defined by average values of systolic or diastolic ambulatory blood pressure readings (taken between 7\n            <jats:sc>am<\/jats:sc>\n            and 10\n            <jats:sc>pm<\/jats:sc>\n            ) above 140 and\/or 90 and\/or use of antihypertensive medication. Among the 3 polymorphic sites, genotype distributions associated with Gly482Ser differed by hypertension status in men (\n            <jats:italic>P<\/jats:italic>\n            =0.0038), but not in women. The less common Ser482 allele was associated with a modest, but significant, reduction in the prevalence of hypertension in men. The distribution of 3 loci haplotypes also differed in men with and without hypertension (\n            <jats:italic>P<\/jats:italic>\n            =0.015). Despite its moderate effect, but because of its high frequency (\u224864%), the more common risk allele contributed to hypertension in 35% (95% CI 16% to 54%) of our male population. These results suggest, but do not prove, that PPARGC1 participates in blood pressure control, and sequence substitutions at its gene locus confer an increased risk of hypertension to a substantial proportion of men.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000050962.48249.b7","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T23:43:13Z","timestamp":1044574993000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Peroxisome Proliferator\u2013Activated Receptor-\u03b3 Coactivator-1 Gene Locus"],"prefix":"10.1161","volume":"41","author":[{"given":"Hannes","family":"Oberkofler","sequence":"first","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Ho\u0308lzl","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Esterbauer","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Xie","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Iglseder","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Krempler","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Paulweber","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Patsch","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine (H.O., H.E., M.X., W.P.), the First Department of Internal Medicine (B.H., B.P.), and the Department of Neurology (B.I.), Landeskliniken, Salzburg; and the Department of Internal Medicine, Krankenhaus Hallein (F.K.), Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00241-0"},{"key":"e_1_3_3_2_2","unstructured":"Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh J Brenner B eds. Hypertension: Pathophysiology Diagnosis and Management. New York NY: Raven Press; 1995: 67\u201388."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90275-H"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.6.e40"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81410-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5977"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.38.4.773"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/88911"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1281"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_11_2","unstructured":"Rosner B. Fundamentals of Biostatistics. Boston Mass: PWS-Kent Publishing Co; 1990: 1\u2013647."},{"key":"e_1_3_3_12_2","unstructured":"Terwilliger JD Ott J. Handbook of Human Genetic Linkage. Baltimore Md: Johns Hopkins University Press; 1994: 188\u2013194."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061035098"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200475200"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.3.305"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402306"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065250"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/47254"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5476.119"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/340670"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100032"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0803-z"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000050962.48249.B7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:47:12Z","timestamp":1715532432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000050962.48249.B7"}},"subtitle":["Associations with Hypertension in Middle-Aged Men"],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1161\/01.HYP.0000050962.48249.B7"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000050962.48249.b7","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"2002-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}