{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:11:34Z","timestamp":1791040294953,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n            Chronic periodontitis has been associated with an increased risk for cardiovascular disease. Left ventricular mass is an established independent predictor of cardiovascular disease. In the present cross-sectional study, we tested the association between periodontitis and left ventricular mass in subjects with essential hypertension. One hundred four untreated subjects with essential hypertension underwent clinical examinations, including echocardiographic study, laboratory tests, and assessment of periodontal status according to the community periodontal index of treatment needs (CPITN). With increasing severity of periodontitis, there was a progressive increase in left ventricle mass. Mean values (g\/height\n            <jats:sup>2.7<\/jats:sup>\n            ) were 39.0 (\u00b12.7) in CPITN 0 (periodontal health), 40.2 (\u00b16.4) in CPITN 1 (gingival bleeding), 42.7 (\u00b16.8) in CPITN 2 (calculus), 51.4 (\u00b111.7) in CPITN 3 (pockets 4 to 5 mm), and 76.7 (\u00b111.3) in CPITN 4 (pockets \u22656 mm) (overall F 51.2;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). Body surface area (\n            <jats:italic>P<\/jats:italic>\n            =0.04), systolic (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) and diastolic (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) blood pressure, and left ventricular mass (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) were determinants of a composite of CPITN 3 and 4. In a multivariate logistic analysis, left ventricular mass was the sole determinant (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) of CPITN stages 3 and 4. Our findings suggest a direct association between severity of periodontitis and left ventricular mass in subjects with essential hypertension. Periodontal evaluation might contribute to refine cardiovascular risk assessment in hypertensive subjects.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000056525.17476.d7","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T21:45:38Z","timestamp":1046987138000},"page":"488-492","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Association Between Periodontal Disease and Left Ventricle Mass in Essential Hypertension"],"prefix":"10.1161","volume":"41","author":[{"given":"Fabio","family":"Angeli","sequence":"first","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Verdecchia","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria Giulia","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacinto","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Prosciutti","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giannoni","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cianetti","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Bentivoglio","sequence":"additional","affiliation":[{"name":"From Dipartimento Malattie Cardiovascolari, Universita\u0300 degli Studi di Perugia and Ospedale R. Silvestrini (F.A., P.V., L.P., M.B.), Perugia; and Universita\u0300 degli Studi di Perugia, Corso di Laurea in Odontoiatria e Protesi Dentaria (C.P., R.G.P., G.P., C.G., S.C.), Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027005308.x"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(95)00118-2"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0205"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0232"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0375"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0810186"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.588"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1123"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/204748739900600102"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.11.1406"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6879.668"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750090301"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01130-X"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0377"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00126.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90388-2"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00110-8"},{"key":"e_1_3_1_18_2","unstructured":"Devereux RB Roman MJ. Hypertensive cardiac hypertrophy: pathophysiologic and clinical characteristics. In: Laragh JH Brenner BM eds. Hypertension: Pathophysiology Diagnosis and Management. 2nd ed. New York NY: Raven Press; 1995: 409\u2013424."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199510000-00003"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.1.48"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.3.564"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00540-7"},{"key":"e_1_3_1_25_2","first-page":"281","volume":"32","year":"1982","unstructured":"Ainamo J, Barmes D, Beagrie G, Cutress T, Martin J, Sardo-Infirri J. Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN). Int Dent J. 1982; 32: 281\u2013291.","journal-title":"Int Dent J"},{"key":"e_1_3_1_26_2","first-page":"346","volume":"34","year":"1990","unstructured":"Offenbacher S, Madianos PN, Champagne CM, Southerland JH, Paquette DW, Williams RC, Slade G, Beck JD. Periodontitis\u2013atherosclerosis syndrome: an expanded model of pathogenesis. J Periodont Res. 1990; 34: 346\u2013352.","journal-title":"J Periodont Res"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02263.x"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.898"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90457-1"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00470.x"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.494"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.38.2.238"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.291004.x"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.119"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.17.1802"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.35.3.844"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-5-345"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000056525.17476.D7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:53:50Z","timestamp":1715532830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000056525.17476.D7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1161\/01.HYP.0000056525.17476.D7"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000056525.17476.d7","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]},"assertion":[{"value":"2002-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}