{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:05:47Z","timestamp":1791158747723,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>In a case-control study of 190 preeclamptic patients and 373 control subjects, we assessed maternal family history of chronic hypertension and type 2 diabetes in relation to preeclampsia risk. Participants provided information on first-degree family history of the 2 conditions and other covariates during postpartum interviews. Logistic regression was used to estimate odds ratios and 95% confidence intervals adjusted for confounding by age, race, and obesity. Compared with women with no parental history of hypertension, women with maternal only (odds ratio=1.9), paternal only (odds ratio=1.8), or both maternal and paternal history of hypertension (odds ratio=2.6) had a statistically significant increased risk of preeclampsia. The odds ratio for women with at least one hypertensive parent and a hypertensive sibling was 4.7 (95% confidence interval, 1.9 to 11.6). Both maternal only (odds ratio=2.1; 95% confidence interval, 0.9 to 4.6) and paternal only (odds ratio=1.9; 95% confidence interval, 1.0 to 3.2) history of diabetes was associated with an increased risk of preeclampsia. Women with a diabetic sibling had a 4.7-fold increased risk of preeclampsia (95% confidence interval, 1.1 to 19.8). For women with at least one hypertensive parent and at least one diabetic parent, relative to those with parents with neither diagnosis, the odds ratio for preeclampsia was 3.2 (95% confidence interval, 1.6 to 6.2). Our results are consistent with the thesis that family history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased preeclampsia risk.<\/jats:p>","DOI":"10.1161\/01.hyp.0000056996.25503.f5","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T21:45:38Z","timestamp":1046987138000},"page":"408-413","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["Family History of Hypertension and Type 2 Diabetes in Relation to Preeclampsia Risk"],"prefix":"10.1161","volume":"41","author":[{"given":"Chunfang","family":"Qiu","sequence":"first","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya K.","family":"Sorensen","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihunnaya O.","family":"Frederick","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Luthy","sequence":"additional","affiliation":[{"name":"From the Center for Perinatal Studies, Swedish Medical Center (C.Q., M.A.W., I.O.F., J.C.D.), Seattle; the Department of Epidemiology, University of Washington (C.Q., M.A.W.), Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center (W.M.L.), Seattle; and Obstetrix Medical Group (T.K.S., D.A.L.), Seattle, Wash."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"1","volume":"219","year":"1996","unstructured":"American College of Obstetricians, and Gynecologists. Hypertension in pregnancy. ACOG Technical Bull. 1996; 219: 1\u20138.","journal-title":"ACOG Technical Bull"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90586-3"},{"key":"e_1_3_2_3_2","first-page":"491","volume":"41","year":"1996","unstructured":"Mittendorf R, Lain KY, Williams MA, Walker C, Preeclampsia: a nested case-control study of risk factors and their interaction. J Reprod Med. 1996; 41: 491\u2013496.","journal-title":"J Reprod Med"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(94)00166-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00078-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.6.717"},{"key":"e_1_3_2_7_2","first-page":"13","volume":"236","year":"1994","unstructured":"Reaven GM. Syndrome X. 6 years later. J Intern Med. 1994; 236 (suppl 736): 13\u201322.","journal-title":"J Intern Med"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.12.1595"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470020063033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1535"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90418-1"},{"key":"e_1_3_2_12_2","first-page":"33","volume":"693","year":"1985","unstructured":"Svensson A, Andersch B, Hansson L. Hypertension in pregnancy: analysis of 261 consecutive cases. Acta Med Scand. 1985; 693: 33\u201339.","journal-title":"Acta Med Scand"},{"key":"e_1_3_2_13_2","first-page":"505","volume":"1","year":"1982","unstructured":"Furuhashi N, Suzuki M, Kono H, Tanaka M, Takahashi T, Hiruta M. Clinical background of preeclampsia in Japanese women. Clin Exp Hypertens B. 1982; 1: 505\u2013510.","journal-title":"Clin Exp Hypertens B"},{"key":"e_1_3_2_14_2","first-page":"321","volume":"79","year":"2001","unstructured":"Van Der Sabder MA, Walraven GE, Milligan PJ, Banya WA, Ceesay SM, Nyan OA, McAdam KP. Family history: an opportunity for early intervention and improved control of hypertension, obesity and diabetes. Bull World Health Organ. 2001; 79: 321\u2013328.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200112000-00005"},{"key":"e_1_3_2_16_2","first-page":"503","volume":"27","year":"2001","unstructured":"Lascaux-Lefebvre V, Ruidavets JB, Arveiler D, Amouyel P, Haas B, Cottel D, Bingham A, Ducimetiere P, Ferrieres J. Influence of parental histories of cardiovascular risk factors on risk factor clusters in the offspring. Diabetes Metab. 2001; 27: 503\u2013509.","journal-title":"Diabetes Metab"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.93"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.10.694"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884448"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000410)91:4<256::AID-AJMG3>3.0.CO;2-T"},{"key":"e_1_3_2_21_2","first-page":"701","volume":"7","year":"1985","unstructured":"Lucas CP, Estigarribia JA, Darga LL, Reaven GM. Insulin and blood pressure in obesity. Hypertension. 1985; 7: 701\u2013706.","journal-title":"Hypertension"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111776"},{"key":"e_1_3_2_23_2","first-page":"14","volume":"31","year":"1998","unstructured":"Mgonda YM, Ramaiya KL, Swai AB, McLarty DG, Alberti KG. Insulin resistance and hypertension in non-obese Africans in Tanzania. Hypertension. 1998; 31: 14\u201318.","journal-title":"Hypertension"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.1.C42"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-002-0034-1"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04291.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252649"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00770.x"},{"key":"e_1_3_2_29_2","first-page":"2416","volume":"85","year":"2000","unstructured":"Piatti PM, Monti LD, Zavaroni I, Valsecchi G, Van Phan C, Costa S, Conti M, Sandoli EP, Solerte B, Pozza G, Pontiroli AE, Reaven G. Alterations in nitric oxide\/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes. J Clin Endocrinol Metab. 2000; 85: 2416\u20132420.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1594"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.66890000.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008746"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6896.92"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000056996.25503.F5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:54:00Z","timestamp":1715532840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000056996.25503.F5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1161\/01.HYP.0000056996.25503.F5"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000056996.25503.f5","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]},"assertion":[{"value":"2002-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}