{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:18:54Z","timestamp":1775881134362,"version":"3.50.1"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>Previous linkage and association studies have suggested that a region of human chromosome 6 containing the tumor necrosis factor (TNF)-\u03b1 gene is involved in the pathogenesis of obesity and obesity-associated hypertension. The aim of the present investigation was to establish whether a segment of rat chromosome 20 (RNO20), which also contains the TNF-\u03b1 gene, determines diet-induced changes in adiposity and blood pressure (BP). The results showed that a transfer of the RNO20 segment from the normotensive Brown Norway (BN) rat onto the background of the spontaneously hypertensive rat (SHR) is associated with a significantly greater increase in adiposity, glucose intolerance, circulating leptin levels, and BP during 12-week, high-fat-diet feeding. In contrast, the transfer is not associated with significant changes in these variables during 12-week, normal-diet feeding. In addition, sequencing of the TNF-\u03b1 gene revealed differences between SHR and BN in the 5\u2032- and 3\u2032-regulatory regions of the gene. Subsequent analyses of TNF-\u03b1 gene expression in fat, muscle, and liver, however, did not provide support for the functional involvement of these differences. In summary, the investigated RNO20 segment contains 1 or more gene variants that affect adiposity, glucose tolerance, serum leptin levels, and BP, but only when the animals are exposed to a particular environment, ie, high-fat-diet feeding. Further studies are needed to identify genes mediating these effects. Considering current changes in our lifestyle involving an increased calorie and fat intake, we believe that gene-environment interactions, such as those described here, play an important role in the current epidemic of obesity and obesity-associated hypertension.<\/jats:p>","DOI":"10.1161\/01.hyp.0000064347.49341.0b","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T20:28:48Z","timestamp":1051820928000},"page":"1047-1055","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Segment of Rat Chromosome 20 Regulates Diet-Induced Augmentations in Adiposity, Glucose Intolerance, and Blood Pressure"],"prefix":"10.1161","volume":"41","author":[{"given":"Zdenka","family":"Pausova","sequence":"first","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Sedova","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Berube","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Hamet","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Tremblay","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dumont","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gaudet","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; and Charles University (M.P., V.K.) and the Institute of Physiology, Academy of Sciences (M.P., V.K., J.K.), Prague, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Pravenec","sequence":"additional","affiliation":[{"name":"From the Centre de recherche, Centre hospitalier de l\u2019Universite\u0301 de Montre\u0301al (Z.P., L.S., J.B., P.H., J.T., M.D., D.G.), Montre\u0301al, Canada; 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