{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:34:49Z","timestamp":1780943689101,"version":"3.54.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>In this study, we investigated the cardiovascular responses mediated by rostral ventrolateral medulla neurons (RVLM) in the Goldblatt hypertension model (2K-1C) treated or not treated with captopril. The actions of glutamate into the RVLM were tested, injecting glutamate (0.1 mol\/L, 100 nL) and its antagonist kynurenic acid (0.02 mol\/L, 100 nL). Glycine (0.5 mol\/L, 100 nL) was also microinjected. Experiments were performed in male Wistar rats (weight, 250 to 300 g); 5 groups were studied: (1) 2K-1C nontreated (H, n=6); (2) 2K-1C treated with captopril, 10 mg\/kg per day (Ht10, n=10); (3) 2K-1C treated with captopril, 50 mg\/kg per day (Ht50, n=7); (4) control normotensive rats (N, n=7); and (5) normotensive rats treated with captopril, 50 mg\/kg per day (Nt50, n=8). All experiments in 2K-1C were performed 6 weeks after renal surgery; captopril treatment lasted for the last 2 weeks. In urethane-anesthetized rats (1.2 g\/kg IV), bilateral microinjection of glycine into the RVLM caused a depressor response; there was no difference between groups in relation to the change of variation (N: 54\u00b12; H: 46\u00b112; Ht10: 50\u00b13, and Ht50: 42\u00b17 mm Hg). Only in the H group, kynurenic acid microinjection into the RVLM caused a depressor response (H: 158\u00b18 to 132\u00b18 mm Hg). Glutamate response was larger in hypertensive than in normotensive rats (N: 38\u00b12.6 and H: 55\u00b16); no difference was observed between hypertensive groups. The data suggest that glutamate acts tonically to drive the RVLM in 2K-1C rats, and this action is modulated by endogenous angiotensin II. The increase in the glutamate actions within the RVLM may contribute to the pathogenesis of renovascular hypertension.<\/jats:p>","DOI":"10.1161\/01.hyp.0000086524.35251.2d","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T02:38:18Z","timestamp":1060655898000},"page":"707-712","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Role of Endogenous Angiotensin II on Glutamatergic Actions in the Rostral Ventrolateral Medulla in Goldblatt Hypertensive Rats"],"prefix":"10.1161","volume":"42","author":[{"given":"Tai\u0301s Helena F.","family":"Carvalho","sequence":"first","affiliation":[{"name":"From Federal University of Sa\u0303o Paulo, School of Medicine, Sa\u0303o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ca\u0301ssia T.","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"From Federal University of Sa\u0303o Paulo, School of Medicine, Sa\u0303o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo U.","family":"Lopes","sequence":"additional","affiliation":[{"name":"From Federal University of Sa\u0303o Paulo, School of Medicine, Sa\u0303o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy R.","family":"Campos","sequence":"additional","affiliation":[{"name":"From Federal University of Sa\u0303o Paulo, School of Medicine, Sa\u0303o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90064-7"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010719"},{"key":"e_1_3_2_3_2","first-page":"R699","volume":"252","year":"1987","unstructured":"Sun MK, Guyenet PG. 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