{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:39:56Z","timestamp":1791322796572,"version":"4.3.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>\n                    Pendrin is an anion exchanger expressed along the apical plasma membrane and apical cytoplasmic vesicles of type B and of non-A, non-B intercalated cells of the distal convoluted tubule, connecting tubule, and cortical collecting duct. Thus,\n                    <jats:italic>Pds<\/jats:italic>\n                    (\n                    <jats:italic>Slc26a4<\/jats:italic>\n                    ) is a candidate gene for the putative apical anion-exchange process of the type B intercalated cell. Because apical anion exchange\u2013mediated transport is upregulated with deoxycorticosterone pivalate (DOCP), we tested whether\n                    <jats:italic>Pds<\/jats:italic>\n                    mRNA and protein expression in mouse kidney were upregulated after administration of this aldosterone analogue by using quantitative real-time polymerase chain reaction as well as light and electron microscopic immunolocalization. In kidneys from DOCP-treated mice,\n                    <jats:italic>Pds<\/jats:italic>\n                    mRNA increased 60%, whereas pendrin protein expression in the apical plasma membrane increased 2-fold in non-A, non-B intercalated cells and increased 6-fold in type B cells. Because pendrin transports HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    and Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    , we tested whether DOCP treatment unmasks abnormalities in acid-base or NaCl balance in\n                    <jats:italic>Pds (-\/-<\/jats:italic>\n                    ) mice. In the absence of DOCP, arterial pH, systolic blood pressure, and body weight were similar in\n                    <jats:italic>Pds (+\/+<\/jats:italic>\n                    ) and\n                    <jats:italic>Pds (-\/-<\/jats:italic>\n                    ) mice. After DOCP treatment, weight gain and hypertension were observed in\n                    <jats:italic>Pds (+\/+<\/jats:italic>\n                    ) but not in\n                    <jats:italic>Pds (-\/-<\/jats:italic>\n                    ) mice. Moreover, after DOCP administration, metabolic alkalosis was more severe in\n                    <jats:italic>Pds (-\/-<\/jats:italic>\n                    ) than\n                    <jats:italic>Pds (+\/+<\/jats:italic>\n                    ) mice. We conclude that pendrin is upregulated with aldosterone analogues and is critical in the pathogenesis of mineralocorticoid-induced hypertension and metabolic alkalosis.\n                  <\/jats:p>","DOI":"10.1161\/01.hyp.0000088321.67254.b7","type":"journal-article","created":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T20:46:40Z","timestamp":1061239600000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":219,"title":["Deoxycorticosterone Upregulates\n                    <i>PDS<\/i>\n                    (\n                    <i>Slc26a4<\/i>\n                    ) in Mouse Kidney"],"prefix":"10.1161","volume":"42","author":[{"given":"Jill W.","family":"Verlander","sequence":"first","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Hassell","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines E.","family":"Royaux","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Glapion","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mou-Er","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine A.","family":"Everett","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Green","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Wall","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville; the Departments of Medicine (K.A.H., S.M.W.) and Surgery (M.-E.W.), University of Texas Medical School at Houston; the Genome Technology Branch (I.E.R., L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; the Department of Medicine (D.M.G., S.M.W.), Emory University, Atlanta, Ga; and the Wellcome Trust Sanger Institute (L.A.E.), Hinxton, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113833"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5429"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1011"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.001411"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V72260"},{"key":"e_1_3_2_6_2","first-page":"F1345","volume":"258","year":"1990","unstructured":"Good DW. 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Am J Physiol. 1985; 249: F870\u2013F877.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112067"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200203000-00023"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000088321.67254.B7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T12:35:46Z","timestamp":1715517346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000088321.67254.B7"}},"subtitle":["Role of Pendrin in Mineralocorticoid-Induced Hypertension"],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1161\/01.HYP.0000088321.67254.B7"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000088321.67254.b7","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"2003-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}