{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:23:23Z","timestamp":1760887403362},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>\n            Hypertension increases oxidative stress, which can impair myocardial microvascular function and integrity. However, it is yet unclear whether long-term antioxidant intervention in early hypertension would preserve myocardial perfusion and vascular permeability responses to challenge. Pigs were studied after 12 weeks of renovascular hypertension without (n=8) or with daily supplementation of antioxidants (100 IU\/kg vitamin E and 1 g vitamin C, n=6), and compared with normal controls (n=7). Myocardial perfusion and microvascular permeability were measured in vivo by electron beam computed tomography before and after 2 cardiac challenges (intravenous adenosine and dobutamine). Basal left ventricular muscle mass was also obtained. Mean arterial pressure was significantly increased in both groups of hypertensive animals (without and with antioxidants, 123\u00b19 and 126\u00b14 mm Hg, respectively, versus normal, 101\u00b14 mm Hg; both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05), but muscle mass was not different among the groups. The impaired myocardial perfusion response to adenosine observed in hypertensives (normal, +51\u00b114%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus baseline; hypertension, +14\u00b115%;\n            <jats:italic>P<\/jats:italic>\n            =0.3 versus baseline) was preserved in hypertensive pigs that received antioxidants (+44\u00b115%;\n            <jats:italic>P<\/jats:italic>\n            =0.01 compared with baseline). Long-term antioxidant intervention also preserved subendocardial microvascular permeability responses in hypertension. On the other hand, antioxidant intervention had little effect on the hypertension-induced myocardial vascular dysfunction observed in response to dobutamine. This study demonstrates that the impaired myocardial perfusion and permeability responses to increased cardiac demand in early hypertension are significantly improved by long-term antioxidant intervention. These results support the involvement of oxidative stress in myocardial vascular dysfunction in hypertension and suggest a role for antioxidant strategies to preserve the myocardial microvasculature.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000111834.03000.e4","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T01:34:12Z","timestamp":1073957652000},"page":"493-498","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Long-Term Antioxidant Intervention Improves Myocardial Microvascular Function in Experimental Hypertension"],"prefix":"10.1161","volume":"43","author":[{"given":"Martin","family":"Rodriguez-Porcel","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Herrman","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro R.","family":"Chade","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Krier","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome F.","family":"Breen","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Divisions of Cardiovascular Diseases (M.R.-P., J.H., A.L.) and Hypertension (A.R.C., J.D.K., L.O.L.), and the Department of Diagnostic Radiology (J.F.B.), Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00413-8"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1992.tb01620.x"},{"key":"e_1_3_2_3_2","first-page":"91654","volume":"35","year":"2000","unstructured":"Hamasaki S, Al Suwaidi J, Higano ST, Miyauchi K, Holmes DR Jr, Lerman A. 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