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COX-2 inhibition may transiently decrease urine sodium excretion in some subjects and induce mild to moderate elevation of blood pressure. Furthermore, in conditions of relative intravascular volume depletion and\/or renal hypoperfusion, interference with COX-2 activity can have deleterious effects on maintenance of renal blood flow and glomerular filtration rate. In addition to physiological regulation of COX-2 expression in the kidney, increased renal cortical COX-2 expression is seen in experimental models associated with altered renal hemodynamics and progressive renal injury (decreased renal mass, poorly controlled diabetes), and long-term treatment with selective COX-2 inhibitors ameliorates functional and structural renal damage in these conditions.<\/jats:p>","DOI":"10.1161\/01.hyp.0000116221.27079.ea","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T01:24:32Z","timestamp":1074561872000},"page":"525-530","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":154,"title":["Cyclooxygenases, the Kidney, and Hypertension"],"prefix":"10.1161","volume":"43","author":[{"given":"Hui-Fang","family":"Cheng","sequence":"first","affiliation":[{"name":"From Division of Nephrology, Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond C.","family":"Harris","sequence":"additional","affiliation":[{"name":"From Division of Nephrology, Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2692"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162468699"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199717050-00001"},{"key":"e_1_3_2_4_2","first-page":"F460","volume":"272","year":"1997","unstructured":"Komhoff M, Grone HJ, Klein T, Seyberth HW, Nusing RM. 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