{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:51:57Z","timestamp":1787953917191,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>\n            In dogs fed a high-fat diet, we determined whether there was a direct relation between obesity-induced insulin resistance and obesity-induced hypertension. Thirty-six adult mongrel dogs were chronically instrumented and assigned to receive either a high-fat diet alone (n=7) or a high-fat diet combined with a low-sodium diet plus furosemide (n=6), prazosin plus atenolol (n=7), clonidine (n=10), or aspirin (n=6). Blood pressure, heart rate, and body weight were measured daily. Insulin resistance was assessed with a single-dose euglycemic hyperinsulinemic clamp (2 mU \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            ) before and after 1, 3, and 6 weeks of the high-fat diet. The low-salt diet plus furosemide, prazosin plus atenolol, and clonidine treatments prevented the hypertension associated with feeding the dogs a high-fat diet. Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of I\u03baB kinase-\u03b2, decreased the degree of insulin resistance by almost 70%. However, aspirin had no effect on the development of hypertension. We conclude that obesity-induced hypertension and obesity-induced insulin resistance are not directly related. In addition, there is a suggestion that insulin resistance in this experimental model is mediated through the central and or peripheral \u03b1\n            <jats:sub>2<\/jats:sub>\n            -adrenoceptors, whereas hypertension is mediated through the \u03b1\n            <jats:sub>1<\/jats:sub>\n            - and or \u03b2-adrenoceptors.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000123073.48855.e9","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T01:53:50Z","timestamp":1078797230000},"page":"1011-1016","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Hypertension and Insulin Resistance Are Not Directly Related in Obese Dogs"],"prefix":"10.1161","volume":"43","author":[{"given":"Albert P.","family":"Rocchini","sequence":"first","affiliation":[{"name":"From the Division of Pediatric Cardiology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Cardiology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Gokee","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Cardiology, University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.1.E147"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.6.922"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.1.548"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210905"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/1.1.84"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90071-J"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-3-580"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199000005-00004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.15.5.519"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-6-1181"},{"key":"e_1_3_2_11_2","first-page":"I-541.","volume":"86","year":"1992","unstructured":"Hall JE, Van Vliet BN, Garrity CA, Connell RD, Brands MW. Role of increased adrenergic activity in obesity-induced hypertension. Circulation. 1992; 86 (suppl I): I-541.","journal-title":"Circulation"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110541"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110976"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00480.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109718"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.21.5.618"},{"key":"e_1_3_2_17_2","first-page":"S31","volume":"15","year":"1997","unstructured":"Rosen P, Ohly P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. J Hypertens. 1997; 15: S31\u2013S38.","journal-title":"J Hypertens"},{"key":"e_1_3_2_18_2","first-page":"S9","volume":"15","year":"1997","unstructured":"Ernsberger P, Friedman JE, Kooletsky RJ. The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. J Hypertens. 1997; 15: S9\u2013S23.","journal-title":"J Hypertens"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11559"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.25.4.893"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00016-3"},{"key":"e_1_3_2_22_2","first-page":"866","volume":"7","year":"1994","unstructured":"Egan BM, Stephiakowski K, Goodfriend TL. Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering. Am J Hypertens. 1994; 7: 866\u2013893.","journal-title":"Am J Hypertens"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)01293-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00267-8"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704320"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200205000-00031"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00234-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.5.1128"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0800-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-3-637"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.3.381"},{"key":"e_1_3_2_32_2","first-page":"233","volume":"75","year":"1997","unstructured":"Luft FC. G-proteins and insulin signaling. J Mol Med. 1997; 75: 233\u2013235.","journal-title":"J Mol Med"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1515\/JBCPP.1998.9.2-4.167"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105216200"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002050"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb05887.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)91500-9"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.6.1270"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2005"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000123073.48855.e9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:15:39Z","timestamp":1715530539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000123073.48855.e9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1161\/01.HYP.0000123073.48855.e9"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000123073.48855.e9","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"2003-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}