{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:31:21Z","timestamp":1771907481783,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>\n            The \u03b1-1 adrenergic receptors (\u03b1\n            <jats:sub>1<\/jats:sub>\n            ARs) are critical in sympathetically mediated vasoconstriction. The specific role of each \u03b1\n            <jats:sub>1<\/jats:sub>\n            AR subtype in regulating vasoconstriction remains highly controversial. Limited pharmacological studies suggest that differential \u03b1\n            <jats:sub>1<\/jats:sub>\n            AR responses may be the result of differential activation of junctional versus extrajunctional receptors. We tested the hypothesis that the \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR subtype is critical in mediating sympathetic junctional neurotransmission. We measured in vivo integrated cardiovascular responses to a hypotensive stimulus (induced via transient bilateral carotid occlusion [TBCO]) in \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR knockout (KO) mice and their wild-type (WT) littermates. In WT mice, after dissection of the carotid arteries and denervation of aortic baroreceptor buffering nerves, TBCO produced significant pressor and positive inotropic effects. Both responses were markedly attenuated in \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR KO mice (change systolic blood pressure 46\u00b18 versus 11\u00b12 mm Hg; percentage change in the end-systolic pressure-volume relationship [ESPVR] 36\u00b17% versus 12\u00b12%; WT versus KO;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.003). In vitro \u03b1\n            <jats:sub>1<\/jats:sub>\n            AR mesenteric microvascular contractile responses to endogenous norepinephrine (NE; elicited by electrical field stimulation 10 Hz) was markedly depressed in \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR KO mice compared with WT (12.4\u00b11.7% versus 21.5\u00b11.2%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). In contrast, responses to exogenous NE were similar in \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR KO and WT mice (22.4\u00b17.3% versus 33.4\u00b14.3%; NS). Collectively, these results demonstrate a critical role for the \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR in baroreceptor-mediated adrenergic signaling at the vascular neuroeffector junction. Moreover, \u03b1\n            <jats:sub>1B<\/jats:sub>\n            ARs modulate inotropic responses to baroreceptor activation. The critical role for \u03b1\n            <jats:sub>1B<\/jats:sub>\n            AR in neuroeffector regulation of vascular tone and myocardial contractility has profound clinical implications for designing therapies for orthostatic intolerance.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000145405.01113.0e","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T00:14:53Z","timestamp":1096935293000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Critical Role for the \u03b1-1B Adrenergic Receptor at the Sympathetic Neuroeffector Junction"],"prefix":"10.1161","volume":"44","author":[{"given":"Seth A.","family":"Townsend","sequence":"first","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert S.","family":"Jung","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Shi Gillian","family":"Hoe","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Y.","family":"Lefkowitz","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakil A.","family":"Khan","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoper A.","family":"Lemmon","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Harrison","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KwanghHo","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili A.","family":"Barouch","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Cotecchia","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artin A.","family":"Shoukas","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Nyhan","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Hare","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan E.","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology\/Critical Care Medicine (K.H.L., D.N., D.E.B.), Medicine (S.A.K., R.W.H., L.A.B., J.M.H.), and Biomedical Engineering (S.A.T., A.S.J., Y.S.G.H., R.Y.L., C.A.L., A.A.S., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, MD; and the University of Lausanne, Switzerland (S.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.23.2336"},{"key":"e_1_3_3_2_2","first-page":"H710","volume":"270","year":"1996","unstructured":"Leech CI, Faber JE. 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