{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:35:04Z","timestamp":1791275704512,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>\n            <jats:italic>Slc26a4 (Pds<\/jats:italic>\n            , pendrin) is an anion transporter expressed in the apical region of type B and non-A, non-B intercalated cells of the distal nephron. It is upregulated by aldosterone analogues and is critical in the development of mineralocorticoid-induced hypertension. Thus,\n            <jats:italic>Slc26a4<\/jats:italic>\n            expression and its role in blood pressure and fluid and electrolyte homeostasis was explored during NaCl restriction, a treatment model in which aldosterone is appropriately increased. Ultrastructural immunolocalization, balance studies, and cortical collecting ducts (CCDs) perfused in vitro were used. With moderate physiological NaCl restriction,\n            <jats:italic>Slc26a4<\/jats:italic>\n            expression in the apical plasma membrane increased 2- to 3-fold in type B intercalated cells. Because\n            <jats:italic>Slc26a4<\/jats:italic>\n            transports Cl\n            <jats:sup>\u2212<\/jats:sup>\n            , we tested whether NaCl balance differs in\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(+\/+)<\/jats:sup>\n            and\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            mice during NaCl restriction. Cl\n            <jats:sup>\u2212<\/jats:sup>\n            absorption was observed in CCDs from\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(+\/+)<\/jats:sup>\n            but not from\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            mice. After moderate NaCl restriction, urinary volume and Cl\n            <jats:sup>\u2212<\/jats:sup>\n            excretion were increased in\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            relative to\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(+\/+)<\/jats:sup>\n            mice. Moreover,\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            mice had evidence of relative vascular volume depletion because they had a higher arterial pH, hematocrit, and blood urea nitrogen than wild-type mice. With moderate NaCl restriction, blood pressure was similar in\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(+\/+)<\/jats:sup>\n            and\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            mice. However, on a severely restricted intake of NaCl,\n            <jats:italic>Slc26a4<\/jats:italic>\n            <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n            mice were hypotensive relative to wild-type mice. We conclude that\n            <jats:italic>Slc26a4<\/jats:italic>\n            is upregulated with NaCl restriction and is critical in the maintenance of acid-base balance and in the renal conservation of Cl\n            <jats:sup>\u2212<\/jats:sup>\n            and water during NaCl restriction.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000145863.96091.89","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:14:02Z","timestamp":1097540042000},"page":"982-987","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":182,"title":["NaCl Restriction Upregulates Renal\n            <i>Slc26a4<\/i>\n            Through Subcellular Redistribution"],"prefix":"10.1161","volume":"44","author":[{"given":"Susan M.","family":"Wall","sequence":"first","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Stanley","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Glapion","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine A.","family":"Everett","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Green","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill W.","family":"Verlander","sequence":"additional","affiliation":[{"name":"From the Department of Medicine (S.M.W., Y.H.K., L.S., D.M.G.), Emory University, Atlanta, Ga; Genome Technology Branch (L.A.E., E.D.G.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; The Wellcome Trust Sanger Institute (L.A.E.), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine (J.W.V.), University of Florida College of Medicine, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113833"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5429"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.001411"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071516798"},{"key":"e_1_3_3_6_2","first-page":"838.","volume":"4","year":"1993","unstructured":"Emmons C. New subtypes of rabbit CCD intercalated cells as functionally defined by anion exchange and H+-ATPase activity. J Am Soc Nephrol. 1993; 4: 838.","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00147.2002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00037.2002"},{"key":"e_1_3_3_9_2","first-page":"F356","volume":"280","year":"2001","unstructured":"Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE. Pendrin: an apical Cl\u2212\/OH\u2212\/HCO3\u2212 exchanger in the kidney cortex. Am J Physiol. 2001; 280: F356\u2013F364.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_10_2","first-page":"F729","volume":"247","year":"1984","unstructured":"Knepper MA, Good DW, Burg MB. Mechanism of ammonia secretion by cortical collecting ducts of rabbits. Am J Physiol. 1984; 247: F729\u2013F738.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000088321.67254.b7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370998"},{"key":"e_1_3_3_13_2","first-page":"F913","volume":"280","year":"2001","unstructured":"Wall SM, Fischer MP, Mehta P, Hassell KA, Park SJ. Contribution of the Na+-K+-2Cl\u2212 cotransporter NKCC1 to Cl\u2212 secretion in rat outer medullary collecting duct. Am J Physiol. 2001; 280: F913\u2013F921.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_14_2","first-page":"F203","volume":"253","year":"1987","unstructured":"Schuster VL, Stokes JB. Chloride transport by the cortical and outer medullary collecting duct. Am J Physiol. 1987; 253: F203\u2013F212.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_15_2","unstructured":"Moe OW Berry CA Rector FC Jr. Renal transport of glucose amino acids sodium chloride and water. In: Brenner BM ed. The Kidney. Philadelphia Pa: W.B. Saunders; 2000: 375\u2013415."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.2.153"},{"key":"e_1_3_3_17_2","unstructured":"Subcommittee on Laboratory Animal Nutrition. Nutrient requirements of the mouse. In: Benevenga NJ ed. Nutrient Requirements of Laboratory Animals. Washington DC: National Academy Press; 1995: 80\u201397."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00602.2002"},{"key":"e_1_3_3_19_2","first-page":"823","volume":"230","year":"1936","unstructured":"McCance RA. Medical problems in mineral metabolism. III: experimental human salt deficiency. Lancet. 1936; 230: 823\u2013830.","journal-title":"Lancet"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1949.00220330056007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000022062.70639.1c"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000066128.04083.ca"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641968409044068"},{"key":"e_1_3_3_24_2","first-page":"93","volume":"1","year":"1968","unstructured":"Shields R, Miles JB, Gilbertson C. Absorption and secretion of water and electrolytes by the intact colon in a patient with primary aldosteronism. Br Med J. 1968; 1: 93\u201396.","journal-title":"Br Med J"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00671.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6322303"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/7783"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0048"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000145863.96091.89","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:29:25Z","timestamp":1715531365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000145863.96091.89"}},"subtitle":["Role in Cl\n            <sup>\u2212<\/sup>\n            Conservation"],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1161\/01.HYP.0000145863.96091.89"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000145863.96091.89","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"2004-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}