{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:52:24Z","timestamp":1772808744344,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>\n            In view of the ongoing controversy of cardiorenal safety of selective COX-2 inhibitors (coxibs), the present study was designed to examine the effects of 2 different coxibs, celecoxib and rofecoxib, compared with a traditional NSAID, diclofenac, and placebo on renal morphology and function in salt-sensitive hypertension. Salt-sensitive (DS) and salt-resistant (DR) Dahl rats were fed with NaCl-enriched diet (4% NaCl) for 8 weeks. Diclofenac (DS-diclofenac), rofecoxib (DS-rofecoxib), celecoxib (DS-celecoxib), or placebo was added to chow from weeks 6 to 8. Immunostaining for monocytes\/macrophages (ED1) and cytotoxic T lymphocytes (CD8) was performed. In addition, renal morphology and proteinuria were assessed. Renal cortex mRNA was isolated for determination of COX-2, eNOS, and CRP mRNA by real-time reverse-transcriptase polymerase chain reaction. Untreated hypertensive animals showed glomerular injury including collapsing glomerulopathy, mesangial sclerosis, mesangiolysis, extracapillary proliferation, protein drops, and an especially high grade of glomerulosclerosis (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus DR-placebo) and CD8-positive and ED1-positive cells (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01 versus DR-placebo), which was improved by celecoxib but not by diclofenac and rofecoxib. C-reactive protein mRNA in renal cortex was increased in DS-placebo animals (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus DR-placebo) and normalized by celecoxib (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus DS-placebo), whereas eNOS mRNA was decreased in the DS-rofecoxib group (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus DR-placebo, DS-celecoxib, and DS-diclofenac). Proteinuria was observed in hypertensive animals (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001 versus DR-placebo), increased by rofecoxib (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 versus DS-placebo), and normalized by celecoxib (\n            <jats:italic>P<\/jats:italic>\n            =0.0015 versus DS-placebo). This head-to-head comparison of selective and nonselective COX inhibitors demonstrates differential effects of coxibs on renal morphology and function in salt-dependent hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.0000153053.82032.bf","type":"journal-article","created":{"date-parts":[[2005,1,4]],"date-time":"2005-01-04T01:14:56Z","timestamp":1104801296000},"page":"193-197","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Selective COX-2 Inhibitors and Renal Injury in Salt-Sensitive Hypertension"],"prefix":"10.1161","volume":"45","author":[{"given":"Matthias","family":"Hermann","sequence":"first","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney","family":"Shaw","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Kiss","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Camici","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"Bu\u0308hler","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remy","family":"Chenevard","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Lu\u0308scher","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann J.","family":"Gro\u0308ne","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"From Cardiovascular Research (M.H., G.C., N.B.), Physiology, University Zu\u0308rich-Irchel, Switzerland; Cardiovascular Center (M.H., R.C., T.F.L., F.R.), Cardiology, University Hospital Zu\u0308rich, Switzerland; Department of Clinical Research (S.S.), University Hospital Bern, Switzerland; German Cancer Research Center (DKFZ) (E.K., H.J.G.), Department of Cellular and Molecular Pathology, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450607"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000116221.27079.ea"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000014323.99765.16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02661-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000127578.21885.3e"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000136134.31846.83"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16299-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12112280"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000101683.30157.0b"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000066354.31050.5A"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.4.817"},{"key":"e_1_3_2_12_2","first-page":"S15","volume":"75","year":"2000","unstructured":"Fogo AB. Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int Suppl. 2000; 75: S15\u2013S21.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.1.389"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000029802.88087.5e"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200390018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.87.10.840"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902149209031700"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000136129.18326.26"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.03.029"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135467.43430.16"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025261.58465.62"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10560"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm960803q"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.0000153053.82032.bf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:38:05Z","timestamp":1715531885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.0000153053.82032.bf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1161\/01.HYP.0000153053.82032.bf"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.0000153053.82032.bf","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"2004-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}